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Memoria de las células T. Memoria de las células T. Las células T CD8 de memoria residente desencadenan respuestas
Jason M Schenkel1, Kathryn A Fraser1, Lalit K Beura1
1Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Science (New York, N.Y.)
|August 30, 2014
Resumen
Las células T CD8 de memoria residente en los tejidos (células T ((RM)) pueden proporcionar una inmunidad casi esterilizadora contra las infecciones virales. Estas células desencadenan respuestas inmunes rápidas al invertir el flujo de información al volver a exponerse a los patógenos.
Área de la Ciencia:
- Inmunología Inmunología.
- Virología Virología.
- Biología celular Biología celular.
Sus antecedentes:
- La teoría del reconocimiento de patógenos describe la detección inmune innata de microbios y la posterior instrucción de las células T CD8.
- Las células T CD8 de memoria residente en los tejidos (células T ((RM)) se colocan en sitios de infección comunes.
Objetivo del estudio:
- Para investigar el papel de las células T (RM) en la inmunidad antiviral.
- Para determinar si las células T (RM) pueden revertir el flujo de información tradicional en las respuestas inmunes.
Principales métodos:
- Los estudios se llevaron a cabo en modelos de ratón.
- La resensibilización del antígeno se realizó en las mucosas reproductoras femeninas.
- Se analizaron las respuestas inmunes desencadenadas por las células T ((RM).
Principales resultados:
- Las células CD8 ((+) T ((RM) segregan citoquinas tras la resensibilización del antígeno.
- Estas citoquinas iniciaron rápidas respuestas inmunes locales adaptativas y innatas.
- Se logró una inmunidad casi esterilizadora contra una infección viral no relacionada.
Conclusiones:
- Las células CD8 ((+) T ((RM) pueden lograr una inmunidad casi esterilizadora al revertir el flujo de información inmune.
- Las células T (RM) inducen rápidamente un estado antiviral amplificando las señales del patógeno.
- Esto pone de relieve un nuevo mecanismo para establecer una defensa antiviral robusta.
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