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La presentación de antígenos restringidos de la clase II de la CMH por las células dendríticas plasmocitoides impulsa

Andrew P Sage1, Deirdre Murphy1, Pasquale Maffia1

  • 1From the Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom (A.P.S., D.M., L.M.M., L.L.B., A.J.F., J.E.H., Z.M.); Centre for Immunobiology, Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow, United Kingdom (P.M., S.R.S., H.C., G.G.); Institut National de la Santé et de la Recherche Médicale, Unit 970, Paris Cardiovascular Research Center, Paris, France (H.A., Z.M.); the Department of Pharmacy, University of Naples Federico II, Naples, Italy (P.M., G.G.); Institute of Immunobiology, Kantonal Hospital St. Gallen, CH-9007 St. Gallen, Switzerland (B.L.); the Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland (W.R.); Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden (G.K.H.); the Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY (B.R.); and the Department of Pathology, University of Geneva Medical School, CH-1211 Geneva, Switzerland (S.H.).

Circulation
|September 17, 2014
PubMed
Resumen

Las células dendríticas plasmocitóides (pDC) promueven la aterosclerosis al presentar antígenos a las células T. El bloqueo de esta función reduce la aterosclerosis, destacando las pDC como un objetivo terapéutico para las enfermedades cardiovasculares.

Palabras clave:
La presentación del antígeno.La aterosclerosis es la aterosclerosis.las células dendríticas.La inmunidad es la inmunidad.de los linfocitos.

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