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Variabilidad del comportamiento a través de la elección estocástica y su control por la corteza cingulada anterior
Dougal G R Tervo1, Mikhail Proskurin1, Maxim Manakov1
1Howard Hughes Medical Institute, Janelia Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA.
Cell
|September 27, 2014
Resumen
Las ratas cambian de la toma de decisiones estratégicas a un modo estocástico cuando se enfrentan a competidores imbatibles. Este cambio de comportamiento, controlado por la entrada del locus coeruleus a la corteza cingulada anterior (ACC), permite la exploración bajo incertidumbre.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Ciencias del comportamiento Ciencias del comportamiento.
- La neurociencia computacional es una neurociencia computacional.
Sus antecedentes:
- Los animales suelen utilizar las experiencias pasadas para optimizar las decisiones.
- Sin embargo, la exploración y la imprevisibilidad también son cruciales para la supervivencia.
- Los mecanismos neuronales que subyacen al cambio entre estas estrategias de comportamiento no se comprenden completamente.
Objetivo del estudio:
- Para investigar cómo las ratas cambian entre los modos de comportamiento estratégico y estocástico.
- Para identificar los circuitos neuronales que controlan esta flexibilidad conductual.
- Comprender el papel de la corteza cingulada anterior (ACC) y el locus coeruleus (LC) en la toma de decisiones bajo incertidumbre.
Principales métodos:
- Experimentos de comportamiento con ratas que se enfrentan a competidores virtuales.
- Perturbaciones del circuito en ratas transgénicas.
- Registros electrofisiológicos y manipulaciones optogenéticas.
- Análisis de las estrategias de comportamiento y la actividad neuronal en el ACC y LC.
Principales resultados:
- Las ratas emplean estrategias históricas y basadas en modelos contra competidores predecibles.
- Las ratas cambian a un modo estocástico, ignorando los resultados, cuando se enfrentan a competidores impredecibles.
- Este interruptor está mediado por la entrada del locus coeruleus a la corteza cingulada anterior (ACC).
- La supresión del compromiso del ACC se observa durante el comportamiento estocástico.
Conclusiones:
- El cerebro puede cambiar entre optimizar el comportamiento basado en la experiencia y adoptar estrategias impredecibles.
- La entrada del locus coeruleus (LC) a la corteza cingulada anterior (ACC) controla esta flexibilidad conductual.
- La modulación noradrenérgica de la salida del ACC permite la toma de decisiones adaptativas bajo la incertidumbre ambiental.
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