Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Regulation of Expression at Multiple Steps

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...

Regulation of Expression Occurs at Multiple Steps

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

Regulation of Expression Occurs at Multiple Steps

Regulation of Expression Occurs at Multiple Steps

Cell Specific Gene Expression

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...

Cell Specific Gene Expression

Cell Specific Gene Expression

Proteins: From Genes to Degradation

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick. Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target.

Cell reports·2026

Same author

Sustained interferon exposure creates a hyper-metastatic subset of melanoma cells.

bioRxiv : the preprint server for biology·2026

Same author

RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis.

Nature communications·2026

Same author

Adaptive evolution of Topoisomerase II triggers reproductive isolation in Drosophila.

bioRxiv : the preprint server for biology·2026

Same author

The discovery of the mammalian fusome.

eLife·2026

Same author

Leptin Receptor <sup>+</sup> cells create a perisinusoidal niche for thrombopoiesis in the bone marrow by synthesizing CXCL14.

bioRxiv : the preprint server for biology·2026

Search research articles

Video Experimental Relacionado

Updated: Apr 22, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

Las diferencias celulares en la síntesis de proteínas regulan la homeostasis de los tejidos.

Michael Buszczak¹, Robert A J Signer², Sean J Morrison²

¹Department of Molecular Biology, Children's Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

|October 11, 2014

Resumen

Este resumen es generado por máquina.

La regulación de la síntesis de proteínas varía según los tipos de células, lo que afecta la identidad y la función de la célula. Estas diferencias específicas de las células son cruciales para mantener la salud de los tejidos y prevenir los tumores.

Más Videos Relacionados

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Videos de Experimentos Relacionados

Last Updated: Apr 22, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method

Published on: October 23, 2018

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Área de la Ciencia:

Biología celular Biología celular.
Biología Molecular Biología Molecular
La bioquímica es la bioquímica.

Sus antecedentes:

La síntesis de proteínas a menudo se considera como un proceso celular fundamental.
Sin embargo, su regulación no es uniforme en todos los tipos de células.
Existen variaciones significativas en los mecanismos de síntesis de proteínas dentro de las células somáticas, incluidas las células madre.

Objetivo del estudio:

Para investigar la regulación específica por tipo de célula de la síntesis de proteínas.
Comprender las implicaciones funcionales de estas diferencias regulatorias.
Explorar el papel de la modulación de la síntesis de proteínas en la identidad celular, la homeostasis tisular y la supresión de tumores.

Principales métodos:

Análisis comparativo de las vías de síntesis de proteínas en diversos tipos de células somáticas.
Utilizando marcadores moleculares específicos de la célula para identificar diferencias regulatorias.
Investigando el impacto de la modulación de la síntesis de proteínas en las funciones celulares.

Principales resultados:

Se demostraron variaciones significativas específicas del tipo de célula en la síntesis de proteínas.
Identificó distintos mecanismos reguladores que rigen la síntesis de proteínas en diferentes poblaciones celulares.
Mostró el papel esencial de estas variaciones en el establecimiento y mantenimiento de la identidad y función celular.

Conclusiones:

La regulación de la síntesis de proteínas es un proceso altamente especializado, no una función universal de "gestión del hogar".
La modulación de la síntesis de proteínas específica de la célula es crítica para la homeostasis de los tejidos y la diferenciación celular.
La desregulación de estos procesos puede contribuir a enfermedades como el cáncer.