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Diálogo entre la microbiota de la piel y la inmunidad
Yasmine Belkaid1, Julia A Segre2
1Program in Barrier Immunity and Repair and Mucosal Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institute of Health (NIH), Bethesda, MD, USA. ybelkaid@niaid.nih.gov jsegre@nhgri.nih.gov.
Science (New York, N.Y.)
|November 22, 2014
Resumen
La piel humana alberga una compleja interacción entre las células de la piel, las células inmunes y los microbios. Esta interacción mantiene la piel en buen estado.
Área de la Ciencia:
- Dermatología Dermatología dermatología.
- Inmunología Inmunología.
- Microbiología Microbiología.
Sus antecedentes:
- La piel sirve como una barrera física crítica contra los patógenos.
- También alberga una comunidad diversa de microorganismos comensales.
- El mantenimiento de la homeostasis de la piel implica interacciones dinámicas entre las células de la piel, las células inmunes y los microbios.
Objetivo del estudio:
- Para revisar las intrincadas interacciones entre los microbios de la piel y las células inmunes.
- Para entender cómo estas interacciones regulan la maduración de la barrera cutánea.
- Para explorar estos procesos bajo los cambios fisiológicos y los desafíos ambientales.
Principales métodos:
- Este es un artículo de revisión, que sintetiza la investigación existente.
- Se centra en la superficie de la piel y los apéndices asociados.
- La revisión integra los hallazgos sobre la fisiología del huésped y los factores ambientales.
Principales resultados:
- La integridad de la barrera cutánea está regulada dinámicamente por el cruce de células huésped-microbio-inmunidad.
- Los microbios comensales juegan un papel crucial en el desarrollo y la función del sistema inmunológico.
- Estas interacciones son esenciales para responder a factores estresantes como heridas e infecciones.
Conclusiones:
- El microbioma de la piel y el sistema inmunológico son co-dependientes para mantener la función de barrera.
- Comprender estas interacciones es clave para abordar la salud y las enfermedades de la piel.
- Las futuras investigaciones deberían aclarar aún más estas complejas redes huésped-microbio-inmune.
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