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El tiempo en movimiento: el reloj molecular se encuentra con el microbioma.
Xue Liang1, Frederic D Bushman2, Garret A FitzGerald1
1Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
Cell
|November 24, 2014
Resumen
El microbioma intestinal fluctúa diariamente, influenciado por cuándo comemos. Perturbar el cuerpo.
Área de la Ciencia:
- Microbiología Microbiología.
- Cronobiología cronobiología.
- Salud Metabólica La salud metabólica es la salud metabólica.
Sus antecedentes:
- La microbiota intestinal muestra ritmos diarios.
- Los horarios de alimentación del huésped regulan estas oscilaciones microbianas.
- La interrupción del reloj circadiano está relacionada con la disbiosis intestinal.
Objetivo del estudio:
- Para investigar la relación entre el tiempo de alimentación del huésped y las oscilaciones diurnas de la microbiota intestinal.
- Explorar las consecuencias de la interrupción del reloj circadiano en la composición microbiana intestinal y el metabolismo del huésped.
Principales métodos:
- Análisis de la composición de la microbiota intestinal.
- Monitoreo de los ritmos circadianos del huésped.
- Evaluación de los parámetros metabólicos del huésped.
Principales resultados:
- El tiempo de alimentación del huésped dicta los patrones de oscilación diurna de la microbiota intestinal.
- La interrupción del reloj circadiano del huésped conduce a una disbiosis intestinal significativa.
- La disbiosis inducida se asocia con el desarrollo de trastornos metabólicos del huésped.
Conclusiones:
- Los horarios de alimentación del huésped son reguladores críticos de los ritmos diarios de la microbiota intestinal.
- La interrupción circadiana tiene un impacto negativo en la ecología microbiana intestinal y en la salud metabólica del huésped.
- La orientación de los tiempos de alimentación puede ofrecer una estrategia para controlar la disbiosis intestinal y los trastornos metabólicos.
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