Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Anatomy of the Intestines01:23

Anatomy of the Intestines

92.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
92.8K
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

128
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
128
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

115
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
115
Development of Human Microbiota01:30

Development of Human Microbiota

54
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
54
Human Genetics01:28

Human Genetics

2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Gut-Brain Axis01:22

Gut-Brain Axis

164
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
164

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Comparative population genomics reveals adaptive convergence in two Drosophila species across global environments.

Cell reports·2026
Same author

Correlated gene copy number changes in a seminal fluid protein network in <i>Drosophila</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

The Stellate meiotic drive system of Drosophila melanogaster is active in contemporary populations.

Genetics·2026
Same author

e3SIM: Epidemiological-ecological-evolutionary simulation framework for genomic epidemiology.

Methods in ecology and evolution·2026
Same author

Technical challenges and quality considerations for dissolving microneedles.

International journal of pharmaceutics·2026
Same author

A genetic association study of iron absorption in adults of East Asian or Northern European ancestry from the Iron Genes in East Asian and Northern European Adults Study (FeGenes).

The American journal of clinical nutrition·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Apr 20, 2026

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

15.1K

La genética humana da forma al microbioma intestinal.

Julia K Goodrich1, Jillian L Waters1, Angela C Poole1

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA; Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.

Cell
|November 24, 2014
PubMed
Resumen
Este resumen es generado por máquina.

La genética del huésped moldea significativamente el microbioma intestinal, influyendo en su composición e impactando el metabolismo del huésped. Ciertas bacterias, como las Christensenellaceae, son hereditarias y están vinculadas al índice de masa corporal (IMC) más bajo.

Más Videos Relacionados

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.6K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.7K

Videos de Experimentos Relacionados

Last Updated: Apr 20, 2026

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

15.1K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.6K
Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
06:58

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

7.7K

Área de la Ciencia:

  • La investigación del microbioma en la investigación del microbioma.
  • Interacciones del microbioma con el huésped.
  • Genética y metabolismo.

Sus antecedentes:

  • Se sabe que la genética del huésped y la microbiota intestinal influyen en los fenotipos metabólicos.
  • La interacción entre la genética del huésped, la composición del microbioma intestinal y el fenotipo del huésped sigue siendo incompletamente entendida.

Objetivo del estudio:

  • Para investigar si la variación genética del huésped da forma al microbioma intestinal.
  • Explorar la interacción entre la genética del huésped y el microbioma intestinal para afectar el metabolismo del huésped.

Principales métodos:

  • Análisis de más de 1.000 muestras fecales de la población TwinsUK.
  • Identificación de taxones microbianos hereditarios y sus redes de co-ocurrencia.
  • El trasplante de una bacteria específica (Christensenella minuta) en ratones libres de gérmenes.

Principales resultados:

  • Se descubrió que la abundancia de numerosos taxones microbianos estaba influenciada por la genética del huésped.
  • La familia Christensenellaceae, el taxón más heredable, mostró co-ocurrencia con otras bacterias y arqueas heredables.
  • El enriquecimiento de Christensenellaceae se observó en individuos con un índice de masa corporal (IMC) más bajo.
  • El trasplante de C. minuta en ratones redujo el aumento de peso y alteró su microbioma intestinal.

Conclusiones:

  • La genética del huésped juega un papel importante en la determinación de la composición del microbioma intestinal humano.
  • Las influencias genéticas en el microbioma pueden afectar los rasgos metabólicos del huésped, como el índice de masa corporal.