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Los radicales de oxígeno en la patogénesis inducida por la gripe y el tratamiento con SOD conjugado con polímero de
1Department of Microbiology, Kumamoto University Medical School, Japan.
Science (New York, N.Y.)
|May 26, 1989
Resumen
La gravedad de la infección por el virus de la gripe en ratones se debe a una reacción inmune excesiva, no solo al crecimiento viral. La terapia con superóxido dismutasa (SOD) muestra potencial al neutralizar los radicales de oxígeno dañinos durante la infección.
Área de la Ciencia:
- Inmunología Inmunología.
- Virología Virología.
- La bioquímica es la bioquímica.
Sus antecedentes:
- La patogenicidad del virus de la gripe está relacionada con la reacción exagerada del sistema inmune del huésped.
- El aumento de la xantina oxidasa y la generación de radicales libres de oxígeno se producen durante la infección por influenza.
Objetivo del estudio:
- Para investigar el papel de los radicales libres de oxígeno en la patogénesis de la gripe.
- Evaluar el potencial terapéutico de la superóxido dismutasa (SOD) en el tratamiento de la influenza.
Principales métodos:
- Ratones infectados con el virus de la gripe.
- La superóxido dismutasa conjugada con polímeros (SOD) administrada como un eliminador de radicales libres.
- Protección evaluada contra la infección letal por influenza.
Principales resultados:
- La administración de SOD conjugado con polímeros protegió a los ratones de la letal influenza.
- Se observó un efecto terapéutico cuando se administró SOD 5-8 días después de la infección.
- Los radicales de oxígeno juegan un papel importante en la patogénesis de la gripe.
Conclusiones:
- Los radicales libres de oxígeno son contribuyentes críticos a la patología de la infección por el virus de la gripe.
- El SOD conjugado con polímeros demuestra una promesa terapéutica para la gripe y otras enfermedades asociadas a los radicales libres.
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