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Un antiguo sistema de defensa elimina las células no aptas de los tejidos en desarrollo durante la competencia
S N Meyer1, M Amoyel2, C Bergantiños2
1Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Science (New York, N.Y.)
|December 6, 2014
Resumen
La competencia celular elimina las células de Drosophila no aptas utilizando componentes del sistema inmunológico innato. Los receptores relacionados con el peaje y Spätzle desencadenan la apoptosis dependiente de NFκB, lo que demuestra una señalización reutilizada para el control de calidad del desarrollo.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Inmunología Inmunología.
- Genética La genética.
Sus antecedentes:
- Los tejidos en desarrollo deben eliminar las células comprometidas para mantener la salud animal.
- La competencia celular es un mecanismo crucial de control de calidad que impide que las células subóptimas contribuyan a los tejidos adultos.
Objetivo del estudio:
- Para investigar los mecanismos moleculares subyacentes a la competencia celular en Drosophila.
- Para determinar si los componentes del sistema inmune innato están involucrados en la eliminación de células no aptas durante el desarrollo.
Principales métodos:
- Utilizó Drosophila melanogaster como organismo modelo.
- Investigó las funciones de las vías de señalización de los receptores relacionados con el peaje (TRR) y Spätzle (Spz).
- Se analizó la apoptosis dependiente de NFκB y la activación del gen pro-muerte en respuesta a la competencia celular.
Principales resultados:
- La competencia celular en Drosophila utiliza componentes del sistema inmunológico innato.
- Los receptores relacionados con el peaje (TRR) y la vía de la citoquina Spätzle (Spz) activan la apoptosis dependiente de NFκB.
- Diferentes células "perdedoras" desencadenan distintas respuestas TRR / NFκB y genes pro-muerte, lo que indica una eliminación dependiente del contexto.
Conclusiones:
- Los componentes del sistema inmune innato son reutilizados para la vigilancia de la aptitud celular durante el desarrollo.
- La vía de señalización NFκB juega un papel crítico en la mediación de la eliminación celular a través de la apoptosis durante la competencia celular.
- La competencia celular es un proceso conservado que involucra redes de señalización sofisticadas para garantizar la integridad del tejido.
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