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Escape de la piratería bacteriana del hierro a través de la rápida evolución de la transferrina
Matthew F Barber1, Nels C Elde2
1Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Science (New York, N.Y.)
|December 16, 2014
Resumen
La inmunidad nutricional impulsa la evolución del patógeno huésped. La transferencia se hace por transferencia.
Área de la Ciencia:
- Biología evolutiva Biología evolutiva.
- Inmunología Inmunología.
- La patogénesis microbiana es la patogénesis microbiana.
Sus antecedentes:
- El secuestro de hierro, o inmunidad nutricional, es un mecanismo de defensa del huésped.
- Los patógenos eliminan el hierro de los huéspedes, creando una batalla por este nutriente esencial.
- El impacto evolutivo de esta batalla de hierro en las interfaces huésped-patógeno es en gran medida desconocido.
Objetivo del estudio:
- Investigar el papel evolutivo de la inmunidad nutricional en las interacciones huésped-patógeno.
- Para explorar el conflicto evolutivo entre la proteína transportadora de hierro transferrina del huésped y los sistemas bacterianos de adquisición de hierro.
Principales métodos:
- Análisis comparativo de la evolución de la transferrina en los primates.
- Investigando las interacciones de unión entre la transferrina y la TbpA bacteriana (proteína A de unión a la transferrina).
- Examen del polimorfismo de la transferrina C2 humana en relación con las variantes de Haemophilus influenzae TbpA.
Principales resultados:
- La transferrina exhibe una rápida evolución en los sitios que interactúan con la TbpA bacteriana, lo que sugiere una carrera armamentista evolutiva.
- Las sustituciones específicas en la transferrina pueden interrumpir la unión de TbpA, contrarrestando la piratería bacteriana del hierro en los simios.
- La variante humana de transferrina C2 evade efectivamente el TbpA de Haemophilus influenzae, lo que explica la variación genética permanente.
Conclusiones:
- La inmunidad nutricional, específicamente la batalla del hierro, es un factor importante de los conflictos evolutivos persistentes entre los primates y los patógenos bacterianos.
- La coevolución huésped-patógeno está formada por adaptaciones moleculares en los sistemas de transporte y adquisición de hierro.
- Comprender estos conflictos proporciona información sobre la defensa del huésped y la adaptación del patógeno.
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