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La base celular y molecular de la selectividad de dirección de los Aδ-LTMRs
Michael Rutlin1, Cheng-Ying Ho2, Victoria E Abraira3
1Solomon H. Snyder Department of Neuroscience, Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
Cell
|December 20, 2014
Resumen
Neuronas mecanosensoriales de umbral bajo (LTMR) detectan la dirección de la deflexión del cabello. La señalización de BDNF guía la polarización de estos LTMR, lo que permite la percepción táctil direccional.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- El sistema sensorial somático es el sistema sensorial somático.
- Mecanotrasducción Mecanotrasducción
Sus antecedentes:
- La percepción del tacto se basa en las neuronas mecanicosensoriales de umbral bajo (LTMR) en la piel.
- Los LTMR son cruciales para detectar estímulos, incluida la dirección del movimiento a través de la piel.
Objetivo del estudio:
- Investigar el mecanismo subyacente a la percepción táctil direccional-selectiva mediada por los Aδ-LTMR murinos.
- Determinar el papel de la señalización BDNF-TrkB en la polarización de las Aδ-LTMR y su afinación direccional.
Principales métodos:
- Examinó las propiedades de distribución y respuesta de los Aδ-LTMR murinos en relación con los folículos pilosos.
- Investigó la expresión y localización de BDNF y su receptor TrkB en células epiteliales del folículo piloso y Aδ-LTMRs.
- Utilizó la ablación genética de BDNF en las células epiteliales del folículo piloso para evaluar su impacto en la polarización y función de Aδ-LTMR.
Principales resultados:
- Los Aδ-LTMR murinos muestran un ajuste preferente a la desviación del vello de caudal a rostral.
- Las terminaciones lanceoladas de Aδ-LTMR están polarizadas y se concentran en el lado caudal de los folículos pilosos.
- El BDNF se sintetiza en el lado caudal de los folículos pilosos, cerca de las terminaciones Aδ-LTMR que expresan TrkB.
- La ablación de BDNF interrumpe la polarización Aδ-LTMR y aleatoriza su dirección de respuesta.
Conclusiones:
- La señalización BDNF-TrkB es esencial para la polarización de las terminaciones lanceoladas de Aδ-LTMR.
- Esta polarización dirigida subyace a la capacidad de los Aδ-LTMR para detectar la dirección de la deflexión del cabello.
- Los hallazgos aclaran un mecanismo molecular para la sensación táctil direccional.
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