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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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La elevación de la señalización de adenosina placentaria contribuye a la patogénesis de la preeclampsia

Takayuki Iriyama1, Kaiqi Sun1, Nicholas F Parchim1

  • 1From Departments of Biochemistry and Molecular Biology (T.I., K.S., N.F.P., J.L., C.Z., A.S., M.R.B., R.E.K., Y.X.) and Department of Obstetrics, Gynecology, and Reproductive Sciences (L.A.H., S.C.B., B.M.S.), University of Texas Medical School at Houston: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan (T.I.); Graduate School of Biomedical Sciences, University of Texas, Houston (K.S., N.F.P., M.R.B, R.E.K., Y.X.); Department of Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, China; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, (L-N. L.C., T.-S.C.); and Department of Pathology, Texas Children's Hospital, Houston (M.J.H.).

Circulation
|December 25, 2014
PubMed
Resumen

La adenosina placentaria crónicamente elevada, impulsada por CD73, causa las características de la preeclampsia. La excesiva señalización del receptor de adenosina A2B (ADORA2B) exacerba este trastorno hipertensivo del embarazo, revelando nuevos objetivos terapéuticos.

Palabras clave:
la adenosina y la adenosina.La hipertensión es la hipertensión.modelos, modelos de animales, modelos de animales para el diseño de modelos.La preeclampsia también es una preeclampsia.embarazo embarazo embarazo embarazo embarazo embarazo embarazo

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