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Intercambio desencadenado de aniónicos por huéspedes neutros dentro de una jaula de coordinación catiónica

Susanne Löffler¹, Jens Lübben, Lennard Krause

¹Institute of Inorganic Chemistry, Georg-August-University Göttingen , Tammannstraße 4, 37077 Göttingen, Germany.

Journal of the American Chemical Society

|January 9, 2015

Resumen

Este estudio presenta un sistema de acogida artificial autoensamblado que utiliza aniones halogenados para desencadenar la encapsulación de moléculas neutras. Este huésped controlable imita los procesos biológicos y muestra potencial para aplicaciones de reconocimiento molecular.

Área de la Ciencia:

Química supramolecular de las moléculas.
Química entre anfitrión y huésped.
Coordinación Química de la Coordinación

Sus antecedentes:

La encapsulación molecular es crucial para la transducción de señales biológicas y la catálisis enzimática.
Los sistemas de huéspedes controlables son valiosos para imitar los procesos naturales y desarrollar nuevos materiales.

Objetivo del estudio:

Diseñar y sintetizar un sistema huésped artificial capaz de encapsular moléculas controladas.
Investigar el mecanismo de captación de invitados desencadenado por estímulos externos.
Para comparar la cinética de unión y la termodinámica de varias moléculas invitadas.

Principales métodos:

Autoensamblaje de un ligando bis-monodentado con los cationes Pd (II) para formar una doble jaula interpenetrada.
La cristalografía de rayos X, la espectrometría de masas de ionización por electrospray (ESI MS) y las técnicas de resonancia magnética nuclear (RMN) para el análisis estructural y de unión.
Estudios cinéticos y termodinámicos de la encapsulación del huésped.

Principales resultados:

Formación de una jaula doble pentacationic con tres bolsillos, cada uno inicialmente contiene un anión tetrafluoroborato.
La activación de aniones halogenados desencadena un cambio conformacional, lo que permite que la bolsa central se una a las moléculas neutrales invitadas.
La jaula se transforma en una especie hexacationa tras la encapsulación del huésped, expulsando el anión central.

Conclusiones:

El sistema de huésped artificial desarrollado demuestra una encapsulación molecular controlada a través de un disparador externo de aniones halogenados.
Este sistema sirve como una imitación para la transducción de señales biológicas y ofrece una plataforma para el reconocimiento molecular selectivo.
Los análisis estructurales y vinculantes detallados proporcionan información sobre las interacciones huésped-anfitrión.

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