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El factor de transcripción A relacionado con la miocardina regula la conversión de los progenitores en adipocitos
Meghan E McDonald1, Chendi Li1, Hejiao Bian1
1Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
Cell
|January 13, 2015
Resumen
Los investigadores identificaron una nueva vía de señalización que controla el desarrollo de los adipocitos beige, que ayudan a regular el metabolismo. Este descubrimiento ofrece información sobre cómo mejorar la salud metabólica y combatir la obesidad.
Área de la Ciencia:
- Biología celular Biología celular.
- Regulación del metabolismo.
- Biología del tejido adiposo Biología del tejido adiposo
Sus antecedentes:
- El tejido adiposo es crucial para la homeostasis metabólica.
- El tejido adiposo marrón (BAT) disipa la energía en forma de calor a través de la expresión de UCP1.
- El origen de los adipocitos beige dentro del tejido adiposo blanco (TAB) sigue sin estar claro.
Objetivo del estudio:
- Para identificar las vías de señalización que regulan el desarrollo de los adipocitos beige.
- Para investigar el papel del MRTFA en la formación de adipocitos beige.
- Para explorar las consecuencias metabólicas de las poblaciones de adipocitos beige alteradas.
Principales métodos:
- Investigó el eje de señalización BMP7-ROCK.
- Modelos de ratón con knockout MRTFA utilizado (MRTFA ((-/-)). modelos de ratón.
- Tejido adiposo analizado para la morfología de los adipocitos y la expresión génica (UCP1).
- Perfiles metabólicos evaluados, incluyendo obesidad y resistencia a la insulina.
Principales resultados:
- Se identificó un eje de señalización BMP7-ROCK-MRTFA que controla la formación de adipocitos beige.
- Los ratones MRTFA ((-/-) exhibieron un aumento de los adipocitos multiloculares y la expresión de UCP1 en WAT.
- La deficiencia de MRTFA condujo a la mejora de los perfiles metabólicos y la protección contra la obesidad inducida por la dieta y la resistencia a la insulina.
Conclusiones:
- La vía BMP7-ROCK-MRTFA es un regulador clave del desarrollo de los adipocitos beige.
- Dirigirse a esta vía podría ofrecer estrategias terapéuticas para los trastornos metabólicos.
- Comprender los orígenes de los adipocitos beige es vital para la investigación de la salud metabólica.
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