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Alteraciones específicas de la enfermedad en el viroma entérico en la enfermedad inflamatoria intestinal
Jason M Norman1, Scott A Handley1, Megan T Baldridge1
1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cell
|January 27, 2015
Resumen
El viroma entérico es anormal en la enfermedad de Crohn.
Área de la Ciencia:
- Microbiología Microbiología.
- Virología Virología.
- Gastroenterología y Gastroenterología.
Sus antecedentes:
- La disminución de la diversidad bacteriana es un sello distintivo de las enfermedades inflamatorias intestinales (EII), incluida la enfermedad de Crohn (EC) y la colitis ulcerosa (UC).
- El papel del viroma entérico en la patogénesis de la EII sigue siendo en gran medida inexplorado.
Objetivo del estudio:
- Para investigar las alteraciones en el viroma entérico de pacientes con CD y UC.
- Para determinar si los cambios virales están asociados con el estado de la enfermedad y las poblaciones bacterianas.
Principales métodos:
- Análisis en profundidad de viriones libres aislados de muestras intestinales.
- Caracterización de poblaciones virales utilizando enfoques metagenómicos.
- Comparación de viromas entre pacientes con EII y controles sanos.
Principales resultados:
- Los pacientes con CD y UC exhiben alteraciones significativas en su viroma entérico.
- Se observó una notable expansión de los bacteriófagos Caudovirales en pacientes con CD y UC.
- La composición del viroma fue específica para el tipo de enfermedad y la cohorte de pacientes, y no secundaria a los cambios bacterianos.
Conclusiones:
- El viroma entérico está desregulado en las enfermedades inflamatorias intestinales.
- Las anormalidades en el viroma, particularmente la expansión de los bacteriófagos, pueden contribuir a la inflamación intestinal y la disbiosis bacteriana.
- El viroma entérico representa un biomarcador potencial y un objetivo terapéutico para la EII.
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