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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

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Acoplamiento cruzado estéreo y quimioselectivo entre dos acrilatos con déficit de electrones: una ruta eficiente

Xu-Hong Hu¹, Jian Zhang, Xiao-Fei Yang

¹Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.

Journal of the American Chemical Society

|January 31, 2015

Resumen

Los investigadores desarrollaron una nueva reacción catalizada por rutenio para sintetizar derivados funcionalizados de muconato. Este método atómico-económico proporciona una ruta directa a los valiosos intermedios sintéticos de los acrilatos.

Área de la Ciencia:

Química orgánica es la química orgánica.
La catálisis de la catálisis.
Metodología sintética de la metodología sintética.

Sus antecedentes:

Las reacciones de acoplamiento cruzado oxidativo directo son cruciales para la formación de enlaces C-C.
Desarrollar métodos eficientes y selectivos para sintetizar sistemas conjugados sigue siendo un desafío.

Objetivo del estudio:

Desarrollar una nueva reacción de acoplamiento cruzado oxidativo directo catalizado por rutenio de acrilatos.
Para sintetizar derivados funcionalizados (Z,E) -muconato con alto rendimiento y selectividad.

Principales métodos:

Utilizó un catalizador de rutenio para el acoplamiento cruzado oxidativo directo de acrilatos.
Condiciones de reacción optimizadas para lograr rendimientos de moderados a buenos y altas estereoselectividades y quimioselectividades.

Principales resultados:

Se han sintetizado con éxito derivados funcionalizados (Z,E) -muconato.
Demostró la naturaleza atómico-económica del protocolo desarrollado.
Se obtienen buenos rendimientos con excelentes selectividades estéreo y quimio.

Conclusiones:

La reacción catalizada por Ru desarrollada ofrece un protocolo sencillo y eficiente para la síntesis de muconato.
Los derivados sintetizados de muconato con funcionalidad diferenciable sirven como versátiles intermedios sintéticos.

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