Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

7.5K
De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
7.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.9K
3.9K
Types of RNA01:20

Types of RNA

16.8K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
16.8K
Types of RNA01:23

Types of RNA

74.3K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
74.3K
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

1.6K
The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
1.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Microprotein, macro-effect: DWORF as a therapeutic strategy in heart failure.

Frontiers in cell and developmental biology·2026
Same author

SBK2 Links Cardiac Stress Signaling to Mitochondrial Proteostasis.

Circulation research·2026
Same author

Phosphatidylinositol diphosphate binding by ESCRT-III filaments.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Direct Evidence for the Sulfonium-Mediated Photopolymerization of 1,2-Dithiolanes.

Journal of the American Chemical Society·2026
Same author

Tailoring fully biobased optical adhesives <i>via</i> hydrogen-bonding modulation.

RSC applied polymers·2026
Same author

Alternative organelle targeting of OPA1 mediates fatty acid release from lipid droplets.

bioRxiv : the preprint server for biology·2026

Video Experimental Relacionado

Updated: Apr 18, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

4.2K

Un micropéptido codificado por un presunto ARN largo no codificante regula el rendimiento muscular.

Douglas M Anderson1, Kelly M Anderson1, Chi-Lun Chang2

  • 1Department of Molecular Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9148, USA; Hamon Center for Regenerative Science and Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9148, USA.

Cell
|February 3, 2015
PubMed
Resumen

Los investigadores descubrieron la mioregulina (MLN), un micropéptido oculto en el ARN no codificante. MLN regula la función muscular al afectar el manejo del calcio, mejorando el rendimiento del ejercicio en ratones.

Más Videos Relacionados

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
06:51

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Published on: August 10, 2018

8.2K
Measuring RAN Peptide Toxicity in C. elegans
10:49

Measuring RAN Peptide Toxicity in C. elegans

Published on: April 30, 2020

7.2K

Videos de Experimentos Relacionados

Last Updated: Apr 18, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

4.2K
Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
06:51

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Published on: August 10, 2018

8.2K
Measuring RAN Peptide Toxicity in C. elegans
10:49

Measuring RAN Peptide Toxicity in C. elegans

Published on: April 30, 2020

7.2K

Área de la Ciencia:

  • Biología Molecular Biología Molecular
  • Fisiología Muscular Fisiología Muscular
  • La genómica es la genómica.

Sus antecedentes:

  • Los ARN no codificantes pueden albergar micropéptidos funcionales ocultos.
  • La función del músculo esquelético se basa en la regulación precisa del calcio (Ca2+).
  • Las proteínas como el fosfolambano (PLN) y la sarcolipina (SLN) modulan la actividad de SERCA.

Objetivo del estudio:

  • Identificar y caracterizar nuevos micropéptidos codificados por ARN no codificantes.
  • Para investigar el papel del micropéptido recién descubierto, mioregulina (MLN), en el músculo esquelético.
  • Comprender el mecanismo de acción de MLN y su impacto en la fisiología muscular.

Principales métodos:

  • Análisis bioinformático para identificar posibles regiones codificadoras de micropéptidos dentro de ARN no codificantes.
  • Secuenciación de ARN y análisis de la expresión en el músculo esquelético.
  • Pruebas bioquímicas para estudiar la interacción de MLN con SERCA.
  • Eliminación genética de MLN en modelos de ratón para evaluar los efectos fisiológicos.

Principales resultados:

  • Descubrimiento de la miorregulina (MLN), un micropéptido específico del músculo esquelético codificado por un presunto ARN largo no codificante.
  • MLN interactúa directamente con y inhibe SERCA, la bomba de Ca2+ del retículo sarcoplásmico.
  • MLN se expresa ampliamente en todos los tipos de músculo esquelético, a diferencia de PLN y SLN.
  • La deleción genética de MLN en ratones mejoró el manejo de Ca2+ y mejoró el rendimiento del ejercicio.

Conclusiones:

  • Myoregulin (MLN) es un nuevo regulador micropéptido funcionalmente significativo de la homeostasis y el rendimiento del músculo esquelético Ca2+.
  • MLN representa una nueva clase de elementos reguladores dentro del transcriptoma no codificante.
  • El descubrimiento de MLN sugiere que muchos más micropéptidos funcionales pueden estar codificados dentro de los ARN no codificantes actualmente anotados.