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Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Asma de Trichophyton: sensibilización de los bronquios y las vías respiratorias superiores al antígeno del
1Department of Internal Medicine, University of Virginia, Charlottesville.
Lancet (London, England)
|April 22, 1989
Resumen
Los adultos con asma e infecciones de la piel pueden tener hipersensibilidad a los hongos como Trichophyton. Esta exposición a hongos puede desencadenar una inflamación de las vías respiratorias, lo que lleva a asma y síntomas de rinosinusitis crónica.
Área de la Ciencia:
- Alergia e Inmunología.
- Pulmonología Pulmonología.
- Dermatología Dermatología dermatología.
Sus antecedentes:
- El asma perenne a menudo se asocia con desencadenantes alérgicos.
- Las infecciones crónicas de la piel a veces pueden indicar problemas subyacentes del sistema inmunológico.
Objetivo del estudio:
- Investigar el vínculo entre la hipersensibilidad fúngica y los síntomas respiratorios en pacientes con asma e infecciones crónicas de la piel.
- Para determinar si las especies de Trichophyton actúan como un desencadenante de la inflamación de las vías respiratorias en estos pacientes.
Principales métodos:
- Se evaluaron 12 pacientes adultos con asma perenne e infecciones crónicas de la piel.
- Se realizaron pruebas de provocación bronquial con extracto de Trichophyton tonsurans.
- Se llevaron a cabo desafíos nasales controlados con placebo y en doble ciego con antígeno dermatófito.
Principales resultados:
- Hipersensibilidad inmediata al Trichophyton spp. fue identificado en todos los pacientes.
- La provocación bronquial reveló reacciones inmediatas en 10 pacientes.
- El desafío nasal confirmó la sensibilidad de la vía aérea superior al antígeno fúngico en 8 pacientes.
- Los pacientes presentaron eosinophilia persistente y rinosinusitis crónica junto con asma.
Conclusiones:
- La absorción de antígenos fúngicos puede conducir a la producción de anticuerpos IgE y la sensibilización de las vías respiratorias.
- La hipersensibilidad fúngica a Trichophyton puede contribuir al asma sintomático y la rinosinusitis crónica.
- Los hallazgos sugieren un papel potencial de los dermatófitos en las presentaciones intrínsecas del asma.
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