Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Hepatitis01:25

Hepatitis

63
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
63
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

63
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
63
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.4K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.4K
Hepatic Portal System01:21

Hepatic Portal System

8.4K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
8.4K
Retrovirus Life Cycles01:10

Retrovirus Life Cycles

50.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
50.8K
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

827
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
827

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members.

Frontiers in immunology·2023
Same author

CD4+ and CD8+ T cells and antibodies are associated with protection against Delta vaccine breakthrough infection: a nested case-control study within the PITCH study.

mBio·2023
Same author

Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history.

Nature communications·2023
Same author

Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity.

Nature immunology·2023
Same author

Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging.

Seminars in immunology·2023
Same author

Type I interferons drive MAIT cell functions against bacterial pneumonia.

The Journal of experimental medicine·2023
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
Same journal

Dual mobility total hip replacement in fractures: stability promotes patient confidence.

Lancet (London, England)·2026
Same journal

Dual mobility versus standard cups in total hip replacement for displaced femoral neck fractures (Duality): an international, multicentre, randomised, controlled, superiority trial.

Lancet (London, England)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Apr 17, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.9K

Hepatitis C y otras enfermedades.

Daniel P Webster1, Paul Klenerman2, Geoffrey M Dusheiko3

  • 1Department of Virology, Royal Free London NHS Foundation Trust, London, UK.

Lancet (London, England)
|February 18, 2015
PubMed
Resumen
Este resumen es generado por máquina.

La infección por el virus de la hepatitis C (VHC) es un problema de salud mundial. Los nuevos medicamentos antivirales de acción directa ofrecen tratamientos orales mejorados y más cortos para el VHC, superando a las terapias de interferón más antiguas.

Más Videos Relacionados

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.4K
Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

10.9K

Videos de Experimentos Relacionados

Last Updated: Apr 17, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.9K
A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

10.4K
Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

10.9K

Área de la Ciencia:

  • Hepatología Hepatología.
  • Virología Virología.
  • Enfermedades infecciosas Enfermedades infecciosas.

Sus antecedentes:

  • La infección por el virus de la hepatitis C (VHC) representa una carga significativa para la salud mundial, lo que lleva a enfermedades hepáticas graves como la cirrosis y el cáncer.
  • La coinfección con el VHC/VIH presenta mayores desafíos con peores resultados para los pacientes.
  • El tratamiento estándar actual con interferón y ribavirina tiene una eficacia limitada (alrededor del 50% de respuesta virológica sostenida) y efectos secundarios significativos.

Objetivo del estudio:

  • Revisar los avances en la comprensión de la virología del VHC.
  • Para resaltar el desarrollo y el impacto de los nuevos medicamentos antivirales de acción directa (DAA).
  • Para discutir la evolución del panorama del tratamiento para la hepatitis C.

Principales métodos:

  • Revisión de la literatura científica sobre virología del VHC y avances en el tratamiento.
  • Análisis de la eficacia y tolerabilidad de nuevas terapias antivirales de acción directa.
  • Comparación de los regímenes de DAA con los tratamientos históricos basados en interferón.

Principales resultados:

  • Los avances en el cultivo celular del VHC han estimulado el desarrollo de fármacos antivirales de acción directa dirigidos a la replicación viral.
  • Los AAD permiten regímenes de tratamiento simplificados, más cortos y orales para el VHC.
  • Los nuevos tratamientos demuestran una mayor eficacia y una mejor tolerabilidad en comparación con el interferón y la ribavirina.

Conclusiones:

  • Los antivirales de acción directa representan un importante avance terapéutico para la infección por el virus de la hepatitis C.
  • Las mejores opciones de tratamiento ofrecen una mayor esperanza para controlar y potencialmente curar el VHC.
  • Sigue habiendo desafíos para garantizar un acceso equitativo a la atención y desarrollar una vacuna preventiva.