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Videos de Conceptos Relacionados

Transcription Factors02:16

Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Factors02:16

Transcription Factors

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Master Transcription Regulators02:23

Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
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RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

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Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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Updated: Apr 17, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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Published on: June 3, 2016

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Dinámica de unión del factor de transcripción durante la diferenciación de células ES humanas.

Alexander M Tsankov1, Hongcang Gu2, Veronika Akopian3

  • 11] Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA [2] Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA [3] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Nature
|February 20, 2015
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores analizaron la unión del factor de transcripción y los datos del epigenoma durante la diferenciación de células madre embrionarias humanas. Descubrieron que el recableado dependiente del contexto de la metilación del ADN y la unión del factor de transcripción es crucial para la determinación del destino celular.

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Área de la Ciencia:

  • Biología del desarrollo Biología del desarrollo.
  • Biología de las células madre Biología de las células madre
  • La epigenética es la epigenética.

Sus antecedentes:

  • Las células madre pluripotentes son modelos esenciales para el estudio del desarrollo de los mamíferos.
  • Comprender los cambios en el destino celular requiere diseccionar la dinámica molecular durante la diferenciación.

Objetivo del estudio:

  • Integrar los datos de unión del factor de transcripción de todo el genoma con los datos epigenéticos y transcripcionales.
  • Para analizar la diferenciación de células madre embrionarias humanas en tres capas germinales.
  • Para revelar las dinámicas reguladoras centrales y los comportamientos de los factores de transcripción específicos del linaje.

Principales métodos:

  • Análisis integrador de datos de unión de todo el genoma para 38 factores de transcripción.
  • Perfilado completo del epigenoma y la transcripción.
  • Estudiar la diferenciación de las células madre embrionarias humanas en ectodermo, mesodermo y endodermo.

Principales resultados:

  • Identificó las dinámicas reguladoras centrales que rigen la especificación de la capa germinal.
  • Se han demostrado patrones de unión específicos de linaje para factores clave de transcripción.
  • Se observó la unión del factor de transcripción asociada con la metilación diferencial del ADN a través de las capas germinales.
  • Encontró recableado dependiente del contexto de la unión del factor de transcripción y modificaciones del epigenoma.

Conclusiones:

  • La unión del factor de transcripción y la remodelación del epigenoma se regulan dinámicamente durante la diferenciación de las células madre embrionarias humanas.
  • Los cambios en la metilación del ADN están relacionados con la unión del factor de transcripción y la especificación de la capa germinal.
  • Este estudio proporciona información sobre los mecanismos moleculares de la determinación del destino celular.