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Deficiencias de complemento en pacientes mayores de diez años con enfermedad meningocócica debido a serogrupos poco
C A Fijen1, E J Kuijper, A J Hannema
1Department of Medical Microbiology, University of Amsterdam Academic Medical Centre, the Netherlands.
Lancet (London, England)
|September 9, 1989
Resumen
La mitad de los pacientes con serogrupos de enfermedad meningocócica rara tenían deficiencias del complemento. Las deficiencias del componente del complemento terminal se relacionaron con infecciones recurrentes, destacando el vínculo entre el complemento y la enfermedad meningocócica.
Área de la Ciencia:
- Inmunología Inmunología.
- Enfermedades infecciosas Enfermedades infecciosas.
- Genética La genética.
Sus antecedentes:
- La enfermedad meningocócica es típicamente causada por serogrupos específicos.
- Las infecciones con serogrupos menos comunes (X, Y, Z, W135, 29E) después de los 10 años de edad son inusuales.
- Las deficiencias del complemento son factores de riesgo conocidos para la enfermedad meningocócica.
Objetivo del estudio:
- Investigar la asociación entre las deficiencias del complemento y la enfermedad meningocócica causada por serogrupos poco comunes.
- Para identificar deficiencias específicas del complemento prevalentes en pacientes con estas infecciones.
Principales métodos:
- Investigación retrospectiva de 46 pacientes diagnosticados con enfermedad meningocócica debida a los serogrupos X, Y, Z, W135 o 29E después de los 10 años de edad.
- Análisis de los niveles y la función del componente del complemento en pacientes afectados.
Principales resultados:
- La deficiencia de complemento se identificó en el 50% de los pacientes estudiados.
- La deficiencia de properdina se encontró en 9 pacientes.
- Síndromes de deficiencia de C3 en 5 pacientes y deficiencias homocigóticas de los componentes terminales (C5-C8) en 9 pacientes.
- Las infecciones meningocócicas recurrentes ocurrieron en 5 de los 9 pacientes con deficiencias terminales del componente del complemento.
Conclusiones:
- La enfermedad meningocócica causada por serogrupos poco comunes se asocia con frecuencia con la deficiencia subyacente del complemento.
- Las deficiencias del componente del complemento terminal representan un riesgo significativo para las infecciones meningocócicas recurrentes.
- Se debe considerar la detección de deficiencias del complemento en pacientes con enfermedad invasiva debido a serogrupos meningococales inusuales.
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