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Los juegos del hambre.

Randy J Seeley1, Kent C Berridge2

  • 1Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.

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|February 28, 2015
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Resumen
Este resumen es generado por máquina.

Una nueva investigación muestra que las neuronas AgRP y POMC cambian rápidamente de actividad cuando se presenta el alimento. Esto desafía los puntos de vista tradicionales sobre cómo estas neuronas hipotalámicas regulan la ingesta de alimentos y el apetito.

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Área de la Ciencia:

  • La neurociencia es la neurociencia.
  • La neuroendocrinología en neuroendocrinología.
  • Fisiología Fisiología Fisiología.

Sus antecedentes:

  • El péptido relacionado con Agouti (AgRP) y las neuronas pro-opiomelanocortina (POMC) en el hipotálamo están tradicionalmente vinculadas al control de la ingesta de alimentos.
  • Los modelos existentes sugieren una respuesta más lenta y más integrada de estas neuronas a las señales de alimentación.

Objetivo del estudio:

  • Investigar la dinámica de actividad en tiempo real de las neuronas AgRP y POMC en respuesta a la presentación de los alimentos.
  • Desafiar y refinar la comprensión actual de la regulación hipotalámico del apetito y el equilibrio energético.

Principales métodos:

  • Utilizó técnicas directas de imágenes in vivo para monitorear la actividad neuronal.
  • Se observaron respuestas neuronales hipotalámicas inmediatamente después de la presentación de estímulos alimenticios.

Principales resultados:

  • Se demostraron cambios rápidos y significativos en la actividad de las neuronas AgRP y POMC tras la presentación directa de alimentos.
  • La velocidad de estas respuestas neuronales fue más rápida de lo previsto por los modelos establecidos de regulación del apetito.

Conclusiones:

  • La rápida activación de las neuronas hipotalámicas AgRP y POMC desafía las nociones funcionales clásicas.
  • Los hallazgos sugieren un papel más inmediato para estas neuronas en la iniciación de comportamientos de alimentación y requieren nuevas hipótesis con respecto al control del apetito.