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Appetitive Associative Olfactory Learning in Drosophila Larvae
Published on: February 18, 2013
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El procesamiento termo-sensorial en el cerebro de la Drosophila.
Wendy W Liu1, Ofer Mazor2, Rachel I Wilson1
1Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.
Nature
|March 6, 2015
Resumen
Las moscas de la fruta procesan la temperatura usando células nerviosas opuestas. Este estudio revela cómo los circuitos cerebrales centrales en Drosophila utilizan la inhibición cruzada para crear una detección de temperatura robusta, distinguiendo entre señales de calentamiento y enfriamiento.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Sensorial Biología Sensorial
- Comportamiento animal Comportamiento animal.
Sus antecedentes:
- Los vertebrados y Drosophila utilizan células termoreceptoras oponentes bidireccionales para la detección de la temperatura.
- Los circuitos centrales que procesan estas señales térmicas permanecen en gran parte sin caracterizar.
Objetivo del estudio:
- Para dilucidar los mecanismos neuronales subyacentes al procesamiento de señales de temperatura en el cerebro de Drosophila.
- Identificar cómo las distintas neuronas de proyección (PNs) responden a los estímulos de calentamiento y enfriamiento.
Principales métodos:
- Identificación genética de las neuronas de proyección (PN) en el cerebro de Drosophila.
- Análisis de las respuestas neuronales a los estímulos térmicos (calentamiento y enfriamiento).
- Investigación de las conexiones sinápticas entre los termoreceptores y los SNPs.
Principales resultados:
- Los distintos PN en Drosophila se excitan por el enfriamiento, el calentamiento o ambos.
- Los PN excitados por el enfriamiento reciben excitación directa de los termorreceptores fríos.
- Los PN excitados por el calentamiento ("PN cálidos") utilizan la inhibición cruzada de los termorreceptores fríos, que los desinhibe cuando el calentamiento suprime la actividad de los termorreceptores fríos.
Conclusiones:
- Los circuitos centrales combinan la excitación de avance de alimentación y la desinhibición para la codificación sensible de la temperatura.
- La inhibición del cruce refina las señales térmicas al cancelar el ruido correlacionado y mejorar la información térmica anticorrelacionada.
- Este mecanismo permite la construcción de códigos neuronales robustos y sensibles para la detección de la temperatura.
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