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Virología. virología. Tasa de mutación y variación del genotipo del virus del Ébola de Mali secuencias de casos
T Hoenen1, D Safronetz1, A Groseth1
1Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, MT 59840, USA.
Science (New York, N.Y.)
|March 28, 2015
Resumen
El virus del Ébola (EBOV) no está evolucionando rápidamente en África Occidental, contrariamente a las primeras preocupaciones. Este estudio encontró tasas de mutación consistentes con brotes anteriores, lo que tranquiliza los esfuerzos de salud pública.
Área de la Ciencia:
- Virología Virología.
- Epidemiología La epidemiología.
- Genética La genética.
Sus antecedentes:
- El brote de 2013-2015 del virus del Ébola en África Occidental (EBOV) no tenía precedentes.
- Los primeros informes sugirieron que las tasas de mutación del EBOV se aceleraron, lo que generó preocupaciones sobre la transmisibilidad, la virulencia y la efectividad de las contramedidas.
Objetivo del estudio:
- Para investigar la tasa evolutiva del EBOV durante el brote de África Occidental.
- Para determinar si el EBOV está experimentando cambios genéticos rápidos en humanos.
Principales métodos:
- Secuenciación de genomas completos de EBOV de casos importados en Malí.
- Análisis de las tasas de sustitución de nucleótidos y la variación genética general.
Principales resultados:
- La tasa de sustitución de nucleótidos calculada fue de 9,6 × 10 (−4) sustituciones por sitio por año.
- Esta tasa es consistente con las tasas previamente observadas en los brotes de EBOV de África Central.
- La variación genética general entre los genotipos observados se mantuvo baja.
Conclusiones:
- El EBOV no está evolucionando rápidamente en humanos durante el actual brote de África Occidental.
- Estos hallazgos alivian las preocupaciones sobre posibles cambios rápidos en la transmisibilidad y virulencia del EBOV.
- Los resultados apoyan las estrategias actuales de respuesta al brote y las decisiones de salud pública.
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