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Estoy comiendo para dos: los efectos de la dieta parental en el metabolismo de la descendencia
Oliver J Rando1, Rebecca A Simmons2
1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Cell
|March 28, 2015
Resumen
La dieta de los padres afecta la salud metabólica de la descendencia, influyendo en el riesgo de enfermedad. Esta revisión explora la evidencia y los mecanismos detrás de cómo la nutrición parental afecta el fenotipo metabólico en los mamíferos.
Área de la Ciencia:
- La patogénesis de la patogénesis de la enfermedad metabólica.
- Epigenética y biología del desarrollo.
- La ciencia nutricional es una ciencia nutricional.
Sus antecedentes:
- Enfermedades complejas como la diabetes involucran factores genéticos y ambientales.
- El entorno de un individuo afecta su metabolismo.
- El entorno de los padres también puede influir en el riesgo de enfermedad metabólica de la descendencia.
Objetivo del estudio:
- Revisar la evidencia que vincula la dieta de los padres con el fenotipo metabólico de la descendencia en los mamíferos.
- Para examinar la comprensión mecánica actual de estos efectos.
Principales métodos:
- Revisión de la literatura de los estudios en mamíferos.
- Análisis de la evidencia sobre los efectos de la dieta de los padres.
- Estudio de los mecanismos moleculares propuestos.
Principales resultados:
- La evidencia apoya la dieta de los padres como un factor significativo en el fenotipo metabólico de la descendencia.
- Los mecanismos implican modificaciones epigenéticas y trayectorias de desarrollo alteradas.
- Los efectos transgeneracionales en la salud metabólica son cada vez más reconocidos.
Conclusiones:
- La dieta de los padres juega un papel crucial en la salud metabólica de la descendencia.
- Comprender estos mecanismos es clave para prevenir las enfermedades metabólicas.
- Se necesita más investigación para dilucidar completamente estas complejas interacciones.
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