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La epigenética. La herencia epigenética no acoplada al reclutamiento específico de la secuencia.

Kaushik Ragunathan1, Gloria Jih1, Danesh Moazed2

  • 1Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

Science (New York, N.Y.)
|April 2, 2015
PubMed
Resumen
Este resumen es generado por máquina.

Las modificaciones de histonas pueden llevar información epigenética independientemente de la secuencia de ADN. En la levadura de fisión, los dominios de metilación de la histona H3 lisina 9 (H3K9me) se heredan a través de las divisiones celulares, lo que demuestra un mecanismo de "lectura-escritura" para la herencia epigenética.

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Área de la Ciencia:

  • La epigenética es la epigenética.
  • Biología Molecular Biología Molecular
  • Genética La genética.

Sus antecedentes:

  • Los estados epigenéticos, marcados por modificaciones posttranslacionales de histonas, regulan los patrones de expresión génica.
  • La transmisión independiente de la información epigenética a través de modificaciones histónicas, independientemente de la secuencia de ADN, la metilación o la interferencia de ARN, sigue siendo poco comprendida.

Objetivo del estudio:

  • Investigar si la información epigenética puede transmitirse a través de modificaciones histónicas independientemente de la secuencia de ADN, la metilación del ADN o la interferencia del ARN.
  • Para dilucidar el mecanismo de la herencia de la información epigenética en la levadura de fisión.

Principales métodos:

  • Dominios inducidos ectopicamente de la metilación de la histona H3 lisina 9 (H3K9me) en Schizosaccharomyces pombe.
  • Eliminación del iniciador específico de la secuencia para evaluar la herencia.
  • Análisis de las funciones de Epe1 (H3K9 desmetilasa) y Clr4 (H3K9 metiltransferasa) en el mantenimiento de los dominios H3K9me.

Principales resultados:

  • Los dominios H3K9me inducidos ectopicamente se heredaron a través de múltiples divisiones celulares mitóticas y meióticas después de la eliminación del iniciador.
  • La desmetilasa H3K9 Epe1 y la metiltransferasa H3K9 Clr4 juegan roles antagónicos en el mantenimiento de los dominios silenciosos H3K9me.
  • Demostró un mecanismo directo de "lectura-escritura" que involucra a Clr4 en la propagación de las modificaciones de la histona.

Conclusiones:

  • Las modificaciones de la histona, específicamente H3K9me, pueden actuar como portadores de información epigenética.
  • La herencia de los dominios H3K9me sugiere un mecanismo para la memoria epigenética independiente de la secuencia de ADN.
  • La interacción entre las metiltransferasas H3K9 y las demetilasas es crucial para mantener los estados epigenéticos.