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Acoplamiento diverso de neuronas a poblaciones en la corteza sensorial
Michael Okun1,2,3, Nicholas Steinmetz1,2,3,4, Lee Cossell1,5
1Dept. of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6DE.
Nature
|April 8, 2015
Resumen
Las neuronas exhiben "acoplamiento de población", una medida de su conexión con la red neuronal general. Este acoplamiento influye en el comportamiento y predice las conexiones sinápticas, simplificando patrones complejos de actividad cerebral.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- La neurociencia computacional es una neurociencia computacional.
- La neurociencia de sistemas es la neurociencia de sistemas.
Sus antecedentes:
- Las poblaciones neuronales generan patrones de disparo complejos, sin embargo, estos a menudo existen en espacios de menor dimensión.
- Comprender la relación entre las neuronas individuales y la actividad de la población es crucial para descifrar la computación neural.
Objetivo del estudio:
- Investigar la relación entre las neuronas individuales y la actividad de la población en la corteza visual.
- Para identificar los mecanismos de circuito subyacentes a la dinámica de la población neuronal.
- Introducir y validar el "acoplamiento poblacional" como una medida de la integración neuronal.
Principales métodos:
- Registros electrofisiológicos in vivo de la corteza visual de ratones y monos.
- Análisis de los patrones de disparo neuronal y su relación con la actividad de la población.
- Manipulación optogenética para probar las relaciones causales.
- In vitro electrofisiología para evaluar la conectividad sináptica.
Principales resultados:
- Las neuronas exhiben diferentes grados de 'acoplamiento de población', desde 'coristas' hasta 'soloistas', independientemente de las preferencias sensoriales.
- El acoplamiento poblacional es un atributo celular fijo, influenciado por variables de comportamiento como la intención motora.
- El acoplamiento de alta población predice la respuesta de una neurona a la estimulación optogenética y se correlaciona con la entrada sináptica de los vecinos.
- El acoplamiento poblacional resume efectivamente la actividad de la población y predice las correlaciones neuronales en pares.
Conclusiones:
- El acoplamiento poblacional es una medida novedosa y simple que caracteriza la integración de una neurona en una red más grande.
- Esta medida explica los complejos patrones de encendido de la red a través de variables básicas del circuito.
- El acoplamiento poblacional ofrece información sobre la codificación neuronal, la organización sináptica y la influencia del comportamiento en la actividad neuronal.
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