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Videos de Conceptos Relacionados

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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Disfunción tiroidea subclínica y riesgo de fractura: un metanálisis.

Manuel R Blum1, Douglas C Bauer2, Tinh-Hai Collet3

  • 1Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.

JAMA
|May 27, 2015
PubMed
Resumen

El hipertiroidismo subclínico, no el hipotiroidismo, aumenta el riesgo de fracturas, especialmente las de cadera. Los niveles más bajos de hormona estimulante de la tiroides (TSH) se correlacionan con tasas más altas de fracturas, lo que justifica una mayor investigación sobre la eficacia del tratamiento.

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Área de la Ciencia:

  • Endocrinología Endocrinología.
  • Salud ósea Salud ósea.
  • Epidemiología La epidemiología.

Sus antecedentes:

  • El vínculo de la disfunción tiroidea subclínica con las fracturas no está bien establecido.
  • Faltan ensayos clínicos que investiguen esta asociación.

Objetivo del estudio:

  • Para determinar la asociación entre la disfunción tiroidea subclínica y las fracturas.
  • Examinando específicamente la cadera, la parte no vertebral, la columna vertebral y cualquier tipo de fractura.

Principales métodos:

  • Una revisión sistemática y un metanálisis de estudios de cohorte prospectivos.
  • Se analizaron los datos de 13 cohortes (70.298 participantes).
  • La función tiroidea se clasificó en eutiroidismo, hipertiroidismo subclínico e hipotiroidismo subclínico en función de los niveles de TSH.

Principales resultados:

  • El hipertiroidismo subclínico se asoció con un mayor riesgo de fractura de cadera (HR 1.36) y cualquier riesgo de fractura (HR 1.28).
  • Los niveles muy bajos de TSH (<0,10 mUI/L) mostraron un riesgo significativamente mayor de fracturas de cadera, cualquiera, y de la columna vertebral.
  • No se encontró una asociación significativa entre el hipotiroidismo subclínico y el riesgo de fractura.

Conclusiones:

  • El hipertiroidismo subclínico está relacionado con un mayor riesgo de fracturas, particularmente fracturas de cadera.
  • El riesgo es más pronunciado con niveles más bajos de TSH y en el hipertiroidismo endógeno subclínico.
  • Se necesita más investigación para explorar si el tratamiento del hipertiroidismo subclínico puede mitigar el riesgo de fractura.