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Biomarcadores circulantes y incidencia de aneurisma de la aorta abdominal: el riesgo de aterosclerosis en las

Aaron R Folsom¹, Lu Yao², Alvaro Alonso²

¹From Division of Epidemiology and Community Health, School of Public Health (A.R.F., L.Y., A.A., P.L.L., W.T.), Division of Cardiology, Department of Medicine, School of Medicine (E.M.), and Department of Medicine, School of Medicine (F.A.L.), University of Minnesota, Minneapolis; Minneapolis VA Health Care System, MN (F.A.L.); and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine and Center for Cardiovascular Disease Prevention, Houston Methodist DeBakey Heart and Vascular Center, TX (C.M.B.). folso001@umn.edu.

|June 19, 2015

Resumen

Seis biomarcadores sanguíneos predicen el riesgo de aneurisma de la aorta abdominal (AAA). Las concentraciones más altas y los marcadores más identificados aumentan significativamente la probabilidad de desarrollar AAA, identificando a las personas de alto riesgo.

Área de la Ciencia:

Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
El descubrimiento de biomarcadores.
Epidemiología La epidemiología.

Sus antecedentes:

La patogénesis del aneurisma aórtico abdominal (AAA) es compleja.
Los estudios transversales sugieren vínculos entre los biomarcadores circulantes y el AAA.
La evidencia prospectiva para estas asociaciones es limitada.

Objetivo del estudio:

Investigar la posible asociación entre múltiples biomarcadores sanguíneos y el AAA incidente.
Identificar biomarcadores específicos y su efecto acumulado en el riesgo de AAA.

Principales métodos:

Estudio de cohorte prospectivo (Estudio de riesgo de aterosclerosis en las comunidades).
Se midieron biomarcadores sanguíneos de inflamación, hemostasis, función cardíaca y rigidez vascular.
Incidente identificado AAA utilizando códigos de alta hospitalaria durante el seguimiento.

Principales resultados:

Seis biomarcadores (número de glóbulos blancos, fibrinógeno, D-dimero, troponina T, péptido natriurético pro-cerebral N-terminal, proteína C-reactiva de alta sensibilidad) se asociaron positivamente con la incidencia de AAA.
El aumento del número de estos biomarcadores en el cuartil más alto se asoció con un riesgo significativamente mayor de AAA (HRs 2.2 a 9.9).
Se observó una fuerte tendencia (P < 0,0001) después de ajustar por otros factores de riesgo.

Conclusiones:

Las concentraciones más altas de estos seis biomarcadores se asocian prospectivamente con un mayor riesgo de AAA.
Existe un efecto acumulativo: más biomarcadores en el cuartil más alto se correlacionan con un mayor riesgo de AAA.
La identificación de individuos con múltiples biomarcadores positivos puede definir un subgrupo de alto riesgo para AAA.

Palabras clave:

aneurisma de la aorta, aneurisma abdominal, aneurisma de la aorta, aneurisma de la aorta, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica, aneurisma de la aorta aórtica Los estudios de cohorte son estudios de cohorte en los que el Factores de riesgo factores de riesgo.

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