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La vía de señalización Ras-Erk-ETS es un objetivo de drogas para la longevidad
Cathy Slack1, Nazif Alic2, Andrea Foley2
1Institute of Healthy Ageing, Department of Genetics, Evolution, and Environment, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany.
Cell
|June 30, 2015
Resumen
Los científicos descubrieron que la inhibición de la vía Ras-Erk-ETS extiende la vida útil en las moscas de la fruta. Esta vía, que involucra la apertura anterior (Aop), ofrece un objetivo potencial para los medicamentos antienvejecimiento en humanos.
Área de la Ciencia:
- Biología molecular La biología molecular.
- Genética La genética.
- Investigación sobre el envejecimiento de la investigación.
Sus antecedentes:
- Comprender los mecanismos del envejecimiento es crucial para la salud humana.
- La vía de señalización de la insulina / IGF-1 (IIS) está vinculada al envejecimiento.
- Las intervenciones farmacológicas pueden potencialmente modular los procesos de envejecimiento.
Objetivo del estudio:
- Para identificar los mecanismos moleculares del envejecimiento en Drosophila.
- Investigar el papel de la señalización Ras-Erk-ETS en el envejecimiento.
- Explorar la orientación farmacológica de esta vía para la extensión de la vida útil.
Principales métodos:
- La manipulación genética de Ras, Erk y Anterior abierto (Aop) en Drosophila.
- Análisis de la extensión de la vida útil aguas abajo de un IIS reducido.
- Administración de trametinib, un inhibidor de Ras-Erk-ETS, en moscas adultas.
Principales resultados:
- La inhibición de Ras es suficiente para la extensión de la vida útil.
- La reducción de la actividad Ras o Erk aumenta directamente la esperanza de vida.
- El represor de emisiones de gases de efecto invernadero (ETS) Aop es fundamental para la extensión de la vida útil.
- La administración de trametinib en adultos extiende la esperanza de vida.
Conclusiones:
- La vía Ras-Erk-ETS es un regulador crítico del envejecimiento en Drosophila.
- La inhibición de la señalización Ras-Erk-ETS es una estrategia viable para la extensión de la vida útil.
- Esta vía representa un objetivo farmacológico prometedor para las intervenciones antienvejecimiento en mamíferos.
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