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Hidrogenación selectiva de nitriles a aminas primarias catalizadas por un complejo de pinzas de cobalto

Arup Mukherjee¹, Dipankar Srimani¹, Subrata Chakraborty¹

¹Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

Journal of the American Chemical Society

|July 2, 2015

Resumen

Este estudio introduce la primera hidrogenación homogénea catalizada por cobalto de nitriles a aminas primarias. Este método de eficiencia atómica proporciona una alternativa más ecológica para sintetizar aminas primarias a partir de varios compuestos de nitrilo.

Área de la Ciencia:

Química orgánica es la química orgánica.
La catálisis es la catálisis.
Química verde es la química verde.

Sus antecedentes:

La hidrogenación catalítica de nitriles a aminas primarias es una transformación clave en la síntesis orgánica.
Los métodos actuales se basan principalmente en catalizadores de metales preciosos, lo que limita la accesibilidad y aumenta los costos.
Existe la necesidad de sistemas catalíticos alternativos, rentables y sostenibles.

Objetivo del estudio:

Desarrollar el primer sistema homogéneo catalizado por cobalto para la hidrogenación de nitriles a aminas primarias.
Establecer una metodología de reducción atómica eficiente y ambientalmente benigna.
Para demostrar la amplia aplicabilidad de este nuevo sistema catalítico.

Principales métodos:

Catálisis homogénea utilizando un catalizador basado en cobalto.
Hidrogenación de varios sustratos de nitrilo, incluidos los tipos (hetero) aromáticos, bencílicos y alifáticos.
Optimización de las condiciones de reacción para lograr altos rendimientos.

Principales resultados:

Desarrollo exitoso de la primera hidrogenación co-catalizada homogénea de nitriles.
Se obtienen buenos a excelentes rendimientos para la reducción de diversas clases de nitrilo.
Demostró el potencial de un enfoque más sostenible para la síntesis de aminas primarias.

Conclusiones:

La catálisis de cobalto homogéneo ofrece una alternativa viable y más ecológica para la hidrogenación de nitrilo.
Esta metodología amplía el conjunto de herramientas para sintetizar aminas primarias de manera eficiente.
El proceso co-catalizado desarrollado representa un avance significativo en la química orgánica sostenible.

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