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Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

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The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
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Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

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2.7K
Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

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Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
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Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
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Chair Conformation of Cyclohexane02:02

Chair Conformation of Cyclohexane

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The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
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High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
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High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal

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Movimiento paso a paso en un multivalente [2]

Zheng Meng1,2, Ying Han1, Li-Na Wang3

  • 1†Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Journal of the American Chemical Society
|July 18, 2015
PubMed
Resumen
Este resumen es generado por máquina.

Los investigadores desarrollaron un nuevo catenano triple entrelazado. Esta máquina molecular exhibe movimiento escalonado provocado por cambios ácido-base, ofreciendo información sobre los mecanismos de la máquina biomolecular.

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Motility of Single Molecules and Clusters of Bi-Directional Kinesin-5 Cin8 Purified from S. cerevisiae Cells
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Área de la Ciencia:

  • Química supramolecular
  • Ingeniería Química
  • Ingeniería Biomolecular

Sus antecedentes:

  • Las máquinas biomoleculares operan a través de procesos en varios pasos que implican cambios conformacionales.
  • Comprender estos movimientos complejos es crucial para diseñar máquinas moleculares artificiales.

Objetivo del estudio:

  • Para notificar un nuevo catenano de tres cadenas entrelazadas [2]
  • Para investigar el movimiento escalonado ácido-base desencadenado de este catenano.
  • Para aclarar los cambios conformacionales y la dinámica de la máquina molecular.

Principales métodos:

  • Síntesis de un nuevo sistema de tres cadenas entrelazadas [2]
  • Utilizando la titulación ácido-base para desencadenar y cuantificar el movimiento gradual.
  • Identificación y cuantificación directa de los estados conformacionales estables.
  • Determinación de los valores de la constante de disociación (pKa) para caracterizar la dinámica.

Principales resultados:

  • El catenano sintetizado [2] demostró un movimiento desencadenado por ácido-base.
  • Se identificaron y cuantificaron cuatro estados conformacionales estables, confirmando un proceso de varios pasos.
  • Se determinaron los valores de pKa, cuantificando la dinámica con la acidez ambiental.
  • La topología de la catenana indujo el movimiento selectivo de los anillos anfitriones para sitios invitados específicos.

Conclusiones:

  • El estudio demostró y caracterizó con éxito el movimiento gradual de una máquina molecular compleja.
  • Los hallazgos proporcionan información sobre los mecanismos de las intrincadas máquinas moleculares biológicas.
  • La investigación ofrece una base para el diseño de máquinas moleculares artificiales con propiedades mecanoquímicas avanzadas.