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El microbioma humano. Pequeñas moléculas de la microbiota humana
Mohamed S Donia1, Michael A Fischbach2
1Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. donia@princeton.edu fischbach@fischbachgroup.org.
Science (New York, N.Y.)
|July 25, 2015
Resumen
Los microbios intestinales humanos producen numerosas moléculas pequeñas con actividades biológicas como la modulación inmune. Las tecnologías futuras mejorarán el descubrimiento y la comprensión de estos compuestos cruciales derivados del microbioma.
Área de la Ciencia:
- Microbiología
- Metabolomía
- La genómica
Sus antecedentes:
- Los estudios genómicos y de interacción entre la microbiota y el huésped han estimulado el descubrimiento de pequeñas moléculas del microbioma humano.
- El microbioma humano es una rica fuente de diversas moléculas pequeñas con funciones biológicas significativas.
Objetivo del estudio:
- Revisar los conocimientos actuales sobre las pequeñas moléculas producidas por la microbiota humana.
- Para discutir las tecnologías futuras para descubrir estas moléculas.
- Abordar los desafíos en la identificación de moléculas clave que impulsan las interacciones entre microbios y microorganismos.
Principales métodos:
- Revisión de la literatura sobre las pequeñas moléculas derivadas del microbioma humano.
- Análisis de las tecnologías actuales y emergentes para el descubrimiento molecular.
- Discusión de la relevancia biológica y las funciones de conducción de interacción de estas moléculas.
Principales resultados:
- Se han identificado numerosas moléculas pequeñas de las principales clases de metabolitos en el microbioma humano.
- Estas moléculas exhiben diversas actividades biológicas, incluida la modulación inmune y la antibiótica.
- Se están descubriendo moléculas clave que influyen en las interacciones microbio-huésped y microbio-microbio.
Conclusiones:
- El microbioma humano es una fuente vital de moléculas pequeñas bioactivas.
- Los avances en la tecnología son cruciales para futuros descubrimientos y la comprensión de las funciones de estas moléculas.
- Se necesitan más investigaciones para aclarar las funciones específicas y la relevancia de los compuestos derivados del microbioma en la salud y la enfermedad del huésped.
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