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Conocimientos estructurales sobre la activación de los receptores μ-opioides

Weijiao Huang1, Aashish Manglik1, A J Venkatakrishnan1,2,3

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305, USA.

Nature
|August 7, 2015
PubMed
Resumen

Los investigadores aclararon la base estructural de la activación del receptor μ-opioide (μOR) mediante la cristalografía de rayos X. Los hallazgos revelan cambios sutiles en el bolsillo de unión y una tríada de aminoácidos conservada crucial para la propagación de la señal en los receptores acoplados a la proteína G.

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