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La infección por Plasmodium promueve la inestabilidad genómica y el linfoma de células B dependiente de AID
Davide F Robbiani1, Stephanie Deroubaix1, Niklas Feldhahn1
1Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Cell
|August 16, 2015
Resumen
La infección crónica por malaria promueve linfomas de células B maduras al prolongar el daño del ADN en las células B del centro germinal, lo que lleva a translocaciones cromosómicas. Este mecanismo explica el vínculo entre la enfermedad parasitaria y el desarrollo del cáncer.
Área de la Ciencia:
- Inmunología
- En el campo de la oncología
- Enfermedades infecciosas
Sus antecedentes:
- La infección crónica por Plasmodium falciparum está relacionada con el linfoma de Burkitt, un cáncer de células B maduro.
- El mecanismo por el cual las infecciones parasitarias promueven el linfoma de células B sigue sin estar claro.
Objetivo del estudio:
- Para investigar la relación entre la enfermedad parasitaria y la linfomagénesis.
- Aclarar el mecanismo por el cual la infección por malaria influye en el desarrollo del cáncer de células B.
Principales métodos:
- Se utilizó Plasmodium chabaudi (Pc) para inducir la infección crónica por malaria en ratones.
- Se analizaron las respuestas de las células B del centro germinal (GC), el daño del ADN y las translocaciones cromosómicas.
Principales resultados:
- La infección por Pc causó una expansión prolongada de la GC y un aumento del daño del ADN en las células GC B.
- La infección por malaria favoreció el desarrollo de linfomas de células B maduras dependientes de AID con translocaciones cromosómicas.
- La infección no alteró la tasa general de linfomagénesis, pero modificó sus características.
Conclusiones:
- La infección crónica por malaria promueve cánceres maduros de células B al inducir la expresión sostenida de citidina desaminasa inducida por activación (AID) en las células GC B.
- Esta actividad AID prolongada conduce a daños en el ADN y translocaciones cromosómicas, favoreciendo la linfomagénesis.
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