Video Experimental Relacionado

Updated: Apr 4, 2026

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

Valor pronóstico de la resonancia magnética cardiovascular con mejora tardía del gadolinio en la amiloidosis cardíaca

Marianna Fontana¹, Silvia Pica¹, Patricia Reant¹

¹From Heart Hospital, London, UK (M.F., S.P., P.R., A.A.-G., T.A.T., S.M.B., V.M., S.R., H.B., A.S.H., C.H.M., J.C.M.); Institute of Cardiovascular Science (M.F., A.A.-G., T.A.T., S.M.B., H.B., J.C.M.) and Department of Statistical Science (W.B.), University College London, UK; National Amyloidosis Centre, University College London, Royal Free Hospital, London, UK (M.F., S.M.B., R.H.S., K.P., S.M., C.J.W., H.J.L., A.D.W., J.D.G., P.N.H.); Bristol Heart Institute, University of Bristol, UK (C.B.-D.); University of Pittsburgh School of Medicine, PA (E.B.S.); and National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD (P.K.).

|September 13, 2015

Resumen

El aumento tardío transmural de gadolinio (LGE) en la resonancia magnética cardiovascular indica de manera confiable la amiloidosis cardíaca avanzada en los tipos AL y ATTR. Este hallazgo predice la muerte del paciente, ofreciendo información prognóstica crucial más allá de los factores existentes.

Área de la Ciencia:

Cardiología
Radiología
Imágenes médicas

Sus antecedentes:

La afectación cardíaca tiene un impacto significativo en el pronóstico de la amiloidosis AL y ATTR.
La resonancia magnética cardiovascular con mejora tardía del gadolinio (LGE) es clave para el diagnóstico de la amiloidosis cardíaca.
El potencial de estratificación del riesgo de LGE en la amiloidosis cardíaca sigue siendo en gran medida desconocido.

Objetivo del estudio:

Evaluar el papel de los patrones de LGE en la estratificación del riesgo de amiloidosis cardíaca.
Para comparar las técnicas LGE (PSIR frente a la magnitud solamente) y el mapeo T1 para evaluar la carga amiloide.
Determinar si los patrones de LGE predicen la mortalidad en pacientes con AL y amiloidosis ATTR.

Principales métodos:

250 sujetos (122 ATTR, 119 AL, 9 portadores) fueron sometidos a mapeo de CMR y T1 de LGE.
El LGE se realizó utilizando técnicas de recuperación por inversión sensible a la fase (PSIR) y de magnitud única.
El seguimiento promedió 24 meses para evaluar los resultados, con patrones de LGE clasificados como ninguno, subendocárdico o transmural.

Principales resultados:

PSIR LGE superiormente nulo en los tejidos en comparación con la magnitud solamente, correlacionado con el volumen extracelular (carga amiloide).
Los patrones de LGE pasaron de ninguno a subendocárdico, luego transmural, con aumento del volumen extracelular.
El LGE transmural predijo de forma independiente la mortalidad por cualquier causa (HR 4.1; P< 0.05), incluso después de ajustar por factores pronósticos establecidos.

Conclusiones:

Existe un continuo de afectación cardíaca en la amiloidosis AL y ATTR.
El LGE transmural, evaluado de manera confiable por el PSIR, indica amiloidosis cardíaca avanzada.
El LGE basado en PSIR proporciona un valor pronóstico incremental significativo en la amiloidosis cardíaca.

Palabras clave:

La amiloidosis Técnicas de imágenes cardíacas imágenes por resonancia magnética el pronóstico

Más Videos Relacionados

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

Videos de Conceptos Relacionados

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

Acute Coronary Syndrome III: Diagnostic Studies

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

Imaging Studies for Cardiovascular System V: CT

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...