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Mutación somática en las células cancerosas y normales

Iñigo Martincorena1, Peter J Campbell2

  • 1Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK.

Science (New York, N.Y.)
|September 26, 2015
PubMed
Resumen

Las mutaciones somáticas se acumulan a lo largo de la vida, afectando el desarrollo, el cáncer y el envejecimiento. La secuenciación del genoma del cáncer revela los impulsores de la mutación, pero siguen existiendo lagunas en la comprensión de la evolución normal de las células en cáncer.

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