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Un circuito cerebral que sincroniza el crecimiento y la maduración revelado a través de la unión de Dilp8 a Lgr3

Diana M Vallejo¹, Sergio Juarez-Carreño¹, Jorge Bolivar²

¹Instituto de Neurociencias, Consejo Superior de Investigaciones Cientifícas and Universidad Miguel Hernández, Campus de Sant Joan, Apartado 18, 03550 Sant Joan, Alicante, Spain.

Science (New York, N.Y.)

|October 3, 2015

Resumen

Los científicos descubrieron Lgr3 como un receptor clave para el péptido similar a la insulina Dilp8 de Drosophila. Este hallazgo revela un circuito neuronal que ayuda a mantener el tamaño corporal constante en el desarrollo de las moscas de la fruta.

Área de la Ciencia:

Biología del desarrollo
La neurociencia
La genética

Sus antecedentes:

La constancia del tamaño corporal es crucial para la estabilidad del desarrollo.
Los mecanismos por los cuales los animales en desarrollo varían el tamaño del colchón siguen siendo incompletamente entendidos.
El péptido similar a la insulina Dilp8 de Drosophila juega un papel en la homeostasis del crecimiento, ajustando el crecimiento y la maduración para mantener el tamaño normal.

Objetivo del estudio:

Para identificar el receptor del péptido similar a la insulina Dilp8 de Drosophila.
Para aclarar el circuito neuronal que media las funciones homeostáticas de Dilp8.
Comprender cómo se regulan las tasas de crecimiento y maduración para estabilizar el tamaño del organismo.

Principales métodos:

Ensayos funcionales
Ensayos de adenosina 3',5'-monofosfato (cAMP)
Análisis genético
Reconstitución de proteínas fluorescentes verdes a través de socios sinápticos (GRASP)

Principales resultados:

Lgr3 fue identificado como el receptor Dilp8.
Se definió un par de neuronas Lgr3 como mediadores clave de la regulación homeostática.
Estas neuronas Lgr3 se conectan con las células productoras de insulina y las neuronas productoras de la hormona prothoracicotrópica.
El circuito identificado atenúa el crecimiento y la maduración.

Conclusiones:

Lgr3 actúa como un receptor Dilp8, mediando la homeostasis del tamaño del desarrollo.
Un nuevo circuito neuronal que involucra a las neuronas Lgr3 regula el crecimiento y la maduración.
Este circuito asegura la coincidencia y la corregulación de las tasas de crecimiento y maduración para estabilizar el tamaño del organismo.

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