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Formación de un órgano neurosensorial por el deslizamiento de células epiteliales
Christin S Kuo1, Mark A Krasnow2
1Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305-5307, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305-5307, USA.
Cell
|October 6, 2015
Resumen
Los investigadores descubrieron un nuevo proceso de migración celular llamado "deslizamiento" durante la formación de cuerpos neuroepiteliales pulmonares. Este movimiento celular dirigido puede explicar el alto potencial metastásico de ciertos cánceres de pulmón.
Área de la Ciencia:
- Biología del desarrollo
- Biología celular
- Investigación pulmonar
Sus antecedentes:
- Las células epiteliales mantienen posiciones estables y asociación de la membrana basal.
- Las reorganizaciones celulares ocurren a través de la intercalación, la delaminación o las transiciones epitelio-mesenquimales.
- Los cuerpos neuroepiteliales pulmonares (NEB) son grupos innervados dentro del epitelio bronquial.
Objetivo del estudio:
- Para mapear la formación de los cuerpos neuroepiteliales pulmonares (NEB).
- Identificar y caracterizar el mecanismo de migración celular implicado en el desarrollo del NEB.
- Para explorar las implicaciones de este mecanismo para la metástasis del cáncer de pulmón neuroendocrino.
Principales métodos:
- Inmunocoloración
- El rastreo del linaje
- Análisis clonal
- Imágenes en vivo
Principales resultados:
- Se identificó un nuevo modo de migración celular, llamado "deslizamiento".
- Los progenitores de NEB pierden transitoriamente el carácter epitelial para migrar sobre/entre las células.
- Los progenitores convergen en los puntos de ramificación bronquial, restablecen la estructura epitelial y expresan genes neuroendocrinos.
- Se observó poca proliferación de progenitor o apoptosis durante la formación de NEB.
Conclusiones:
- El programa de migración es crucial para el desarrollo de la NEB.
- Esta migración dirigida implica la regulación a la baja de las proteínas de adhesión y polaridad.
- El mecanismo de deslizamiento puede ser la base de la naturaleza metastásica de los cánceres de pulmón neuroendocrinos.
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