Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Dementia01:30

Dementia

702
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
702
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

1.2K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.2K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

5.7K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
5.7K
Vascular Spasm01:16

Vascular Spasm

4.8K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
4.8K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

1.2K
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
1.2K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Selective molecular and network architecture features underlie brain cortical atrophy in dementia with Lewy bodies.

Journal of biomedical science·2026
Same author

The utility of a composite endpoint for tracking disease progression in Lewy body dementia.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

Association between angiotensin receptor blocker use and postmortem dementia pathology: analysis of the UK Brain Banks Network dataset.

BMJ neurology open·2026
Same author

Multicenter development and validation of a probability-based model to diagnose Lewy body disease using ¹²³I-meta-iodobenzylguanidine.

European journal of nuclear medicine and molecular imaging·2026
Same author

Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies.

Psychological medicine·2025
Same author

Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder.

EBioMedicine·2025

Video Experimental Relacionado

Updated: Mar 29, 2026

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice
04:29

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

Published on: May 17, 2024

1.3K

Demencia vascular

John T O'Brien1, Alan Thomas2

  • 1Department of Psychiatry, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

Lancet (London, England)
|November 24, 2015
PubMed
Resumen

La demencia vascular, una causa común de deterioro cognitivo, carece de tratamientos aprobados debido a problemas de clasificación y vínculos poco claros con la patología del Alzheimer. La investigación adicional es crucial para desarrollar estrategias efectivas de manejo de la demencia vascular.

Más Videos Relacionados

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.5K
A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:12

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

1.6K

Videos de Experimentos Relacionados

Last Updated: Mar 29, 2026

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice
04:29

Author Spotlight: Modeling Vascular Contributions to Alzheimer's Disease in Transgenic Mice

Published on: May 17, 2024

1.3K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

22.5K
A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
05:12

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

Published on: November 22, 2024

1.6K

Área de la Ciencia:

  • Neurología
  • La neurociencia
  • Enfermedad de los ancianos

Sus antecedentes:

  • La demencia vascular es el segundo tipo de demencia más común, que representa el 15% de los casos.
  • A diferencia de la enfermedad de Alzheimer, actualmente no existen tratamientos autorizados para la demencia vascular.
  • Los desafíos incluyen incertidumbres de diagnóstico y la relación poco clara entre los problemas cerebrovasculares y el deterioro cognitivo.

Objetivo del estudio:

  • Criticar las áreas clave y las controversias en la investigación de la demencia vascular.
  • Para resumir los ensayos de tratamiento existentes para la demencia vascular.
  • Proponer los avances necesarios para comprender la patogénesis y desarrollar nuevos tratamientos.

Principales métodos:

  • Revisión de la literatura y análisis crítico de las investigaciones existentes sobre la demencia vascular.
  • Síntesis de datos de ensayos clínicos pasados y en curso.
  • Identificación de las lagunas de conocimiento y direcciones de investigación futuras.

Principales resultados:

  • El progreso se ve obstaculizado por las ambigüedades de la clasificación y la falta de objetivos claros de tratamiento.
  • El vínculo mecanicista entre la patología vascular y la patología de Alzheimer sigue sin identificarse.
  • Los ensayos de tratamiento actuales han dado un éxito limitado.

Conclusiones:

  • Abordar los criterios de diagnóstico y comprender la interacción entre la patología vascular y la de Alzheimer es fundamental.
  • La identificación de objetivos de tratamiento tratables es esencial para avanzar en el manejo de la demencia vascular.
  • La investigación futura debe centrarse en el esclarecimiento de la patogénesis para mejorar las estrategias terapéuticas.