Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Development of Human Microbiota01:30

Development of Human Microbiota

17
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
17
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

24
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
24
Gut-Brain Axis01:22

Gut-Brain Axis

39
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
39
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

15
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
15
Microbiota of the Stomach and Small Intestine01:27

Microbiota of the Stomach and Small Intestine

17
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
17
Microbiota of the Urogenital Tract01:28

Microbiota of the Urogenital Tract

21
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
21

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Gut microbiome features associated with Bifidobacterium colonization predict personalized probiotic persistence patterns.

Nature communications·2026
Same author

Avoidant/Restrictive Food Intake Disorder in Disorders of Gut-Brain Interaction: Adaptive Restriction or Psychopathology?

Gastroenterology·2026
Same author

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health.

Nature reviews. Gastroenterology & hepatology·2026
Same author

Soy and the gut microbiome: a bi-directional relationship shaping nutrition and health.

European journal of nutrition·2026
Same author

Evaluating the rumen microbial community of genetically divergent spring-calving dairy cows grazing grass-only or grass-clover swards at different stages of the grazing season.

Frontiers in microbiology·2025
Same author

Iron-saturated bovine lactoferrin preserves microbiota diversity and healthy ageing-associated taxa in an in vitro colon model of elderly gut microbiota (Iron-saturated bovine lactoferrin impact on elderly gut microbiota).

PloS one·2025
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Mar 26, 2026

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

3.4K

Microbiota intestinal y envejecimiento

Paul W O'Toole1, Ian B Jeffery2

  • 1School of Microbiology and APC Microbiome Institute, University College Cork, Cork T12 Y337, Ireland. pwotoole@ucc.ie.

Science (New York, N.Y.)
|January 20, 2016
PubMed
Resumen
Este resumen es generado por máquina.

La composición de la microbiota intestinal cambia gradualmente con la edad, lo que afecta la inmunidad y la cognición en los adultos mayores. Comprender estos cambios es clave para desarrollar estrategias de vigilancia de la salud.

Más Videos Relacionados

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.5K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

15.0K

Videos de Experimentos Relacionados

Last Updated: Mar 26, 2026

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

3.4K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.5K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

15.0K

Área de la Ciencia:

  • Gerontología
  • Microbiología
  • Inmunología

Sus antecedentes:

  • La microbiota intestinal juega un papel crucial en el mantenimiento de la salud, especialmente en las personas mayores.
  • Las alteraciones de la microbiota pueden influir en las afecciones relacionadas con el envejecimiento, como la disminución de la inmunidad innata, la sarcopenia y el deterioro cognitivo, lo que contribuye a la fragilidad.
  • Los estudios indican diferencias en la composición de la microbiota intestinal entre adultos mayores y más jóvenes, con cambios que ocurren gradualmente con el tiempo.

Objetivo del estudio:

  • Para analizar la composición de la microbiota intestinal en adultos mayores.
  • Identificar las asociaciones entre los grupos de microbiota y factores como la edad, la atención residencial, la dieta y la retención del microbioma central.
  • Establecer un marco para comprender las relaciones entre la microbiota y la salud en el envejecimiento y desarrollar herramientas de vigilancia de la salud.

Principales métodos:

  • Se utilizaron análisis detallados para categorizar la microbiota intestinal en grupos distintos.
  • Investigó la relación entre estos grupos de microbiota y los factores relacionados con el envejecimiento.
  • Se examinó la conexión entre la composición de la microbiota y los fenotipos clínicos en personas mayores.

Principales resultados:

  • Se identificaron grupos específicos de microbiota intestinal asociados con la edad, el cuidado a largo plazo, la dieta y el estado del microbioma central.
  • Cambios graduales observados en la composición de la microbiota con el envejecimiento, en lugar de cambios abruptos.
  • Comenzó a dilucidar cómo estos cambios en la microbiota se relacionan con los procesos de envejecimiento fisiológico y los resultados clínicos.

Conclusiones:

  • La microbiota intestinal sufre cambios graduales a lo largo del proceso de envejecimiento.
  • Estos cambios están vinculados a factores como la dieta y el estilo de vida, y afectan a las condiciones de salud relevantes para los adultos mayores.
  • Los hallazgos proporcionan una base para distinguir los vínculos causales entre la microbiota y la salud y para desarrollar un monitoreo de la salud basado en la microbiota para los ancianos.