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Updated: Mar 26, 2026

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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Los inhibidores específicos del alelo inactivan el mutante KRAS G12C mediante un mecanismo de captura

Piro Lito1, Martha Solomon2, Lian-Sheng Li3

  • 1Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. rosenn@mskcc.org litop@mskcc.org.

Science (New York, N.Y.)
|February 4, 2016
PubMed
Resumen

Las nuevas terapias pueden inhibir la señalización KRAS ((G12C) atrapando la proteína en su estado inactivo, lo que requiere una actividad intacta de la guanosina trifosfatasa (GTPasa). Este mecanismo ofrece un nuevo enfoque para el tratamiento de los cánceres impulsados por KRAS ((G12C).

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