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Medicamentos antiinflamatorios no esteroideos tópicos para el dolor musculoesquelético agudo

Sheena Derry¹, Philip Wiffen¹, Andrew Moore¹

¹Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.

|February 24, 2016

Resumen

Los antiinflamatorios no esteroideos tópicos (AINE) reducen eficazmente el dolor en lesiones musculoesqueléticas agudas como esguinces y torceduras. Estos tratamientos muestran un mayor alivio del dolor sin un aumento significativo de los eventos adversos en comparación con el placebo.

Área de la Ciencia:

Farmacología
Medicina musculoesquelética
Tratamiento del dolor

Sus antecedentes:

Las afecciones musculoesqueléticas agudas (esguinces, estiramientos, contusiones) son causas comunes de dolor.
Los antiinflamatorios no esteroideos tópicos (AINE) ofrecen una opción de tratamiento localizado.

Objetivo del estudio:

Evaluar la eficacia de los AINE tópicos para reducir la intensidad del dolor en las afecciones musculoesqueléticas agudas.
Evaluar el perfil de seguridad de los AINE tópicos, buscando específicamente un aumento de los eventos adversos en comparación con el placebo.

Principales métodos:

Revisión sistemática y metanálisis de ensayos controlados aleatorios.
Comparación de los AINE tópicos frente al placebo para las lesiones musculoesqueléticas agudas.
Evaluación de las puntuaciones de intensidad del dolor y notificación de eventos adversos.

Principales resultados:

Los AINE tópicos demostraron una reducción estadísticamente significativa de la intensidad del dolor en comparación con el placebo.
No se observó un aumento significativo en la incidencia de eventos adversos con el uso tópico de AINE.

Conclusiones:

Los AINE tópicos proporcionan un alivio eficaz del dolor en las afecciones musculoesqueléticas agudas.
Los AINE tópicos son una opción de tratamiento segura con un perfil de eventos adversos comparable al placebo.

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