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Updated: Mar 24, 2026

Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood
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Camino de maduración desde la línea germinal hasta el neutralizador amplio del VIH-1 de un anticuerpo de imitación de

Mattia Bonsignori1, Tongqing Zhou2, Zizhang Sheng3

  • 1Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

Cell
|March 8, 2016
PubMed
Resumen

Un linaje específico de anticuerpos derivado del gen VH1-46 maduró para neutralizar el 90% de los aislados de VIH-1 al atacar el sitio de unión a CD4 (CD4bs). Este proceso de maduración, guiado por el gen

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