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El sensor de nutrientes OGT en las neuronas PVN regula la alimentación

Olof Lagerlöf1, Julia E Slocomb2, Ingie Hong3

  • 1Solomon H. Snyder Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Science (New York, N.Y.)
|March 19, 2016
PubMed
Resumen

Los científicos descubrieron que la eliminación de la O-GlcNAc transferasa (OGT) de células cerebrales específicas en ratones adultos condujo a la obesidad debido a comer en exceso. Esto sugiere que la O-GlcNAcilación en el hipotálamo es clave para controlar el comportamiento de alimentación y la saciedad.

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