Video Experimental Relacionado
Updated: Jul 12, 2026
09:50
Live Imaging of Drosophila Larval Neuroblasts
Published on: July 7, 2014
El control genético de los patrones de división celular en el embrión de Drosophila
1Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
Cell
|April 7, 1989
Resumen
El gen de la cuerda (stg) es crucial para iniciar la mitosis durante la embriogénesis de Drosophila. Sus patrones de expresión controlan el momento y la ubicación de las divisiones celulares después de la transición materna-zigótica.
Área de la Ciencia:
- Biología del desarrollo Biología del desarrollo.
- Regulación del ciclo celular Reglamento del ciclo celular.
- Genética La genética.
Sus antecedentes:
- La embriogénesis de Drosophila implica una transición crítica en el control mitótico durante la interfase 14.
- Las mitosis previas a la interfase 14 dependen de factores maternos, que ocurren de forma sincrónica.
- Las mitosis posteriores a la interfase 14 requieren transcripción cigótica y exhiben patrones asíncronos y organizados espacialmente.
Objetivo del estudio:
- Clonar el gen de la cadena (stg) e investigar su papel en la iniciación mitótica.
- Comprender los mecanismos moleculares subyacentes a la transición en el control mitótico durante la embriogénesis de Drosophila.
Principales métodos:
- Clonado del gen de la cadena (stg).
- Análisis de la homología de la secuencia de aminoácidos predicha.
- Detección de patrones de expresión de ARNm stg zigótico utilizando la hibridación in situ.
Principales resultados:
- Las mutaciones en el locus stg causan la detención del ciclo celular G2 específicamente durante la interfase 14.
- La secuencia de aminoácidos predicha de stg es homóloga a la de la levadura cdc25, un conocido regulador de la iniciación mitótica.
- La expresión del ARNm stg cigótico muestra patrones espaciales dinámicos que preceden a las divisiones celulares cigóticas.
Conclusiones:
- El gen de la cuerda (stg) es esencial para iniciar la mitosis en la transición materna a cigótica en Drosophila.
- La expresión zigótica regulada del ARNm stg dicta el control espacio-temporal de las divisiones celulares embrionarias.
Videos de Conceptos Relacionados
02:45The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
02:11The Cell Cycle Control System
The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
02:36Cells Coordinate Growth and Proliferation
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
02:13Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
01:28The Cell Cycle Control System
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
01:27Molecular Factors Affecting Cell Division
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...