Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

DNA Packaging00:58

DNA Packaging

114.7K
Overview
114.7K
DNA Packaging00:58

DNA Packaging

37.4K
37.4K
Chromatin Packaging01:32

Chromatin Packaging

20.1K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
20.1K
Chromatin Packaging02:21

Chromatin Packaging

23.0K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
23.0K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

53.9K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
53.9K
DNA Isolation01:34

DNA Isolation

202.5K
DNA from cells is required for many biotechnology and research applications, such as molecular cloning. To remove and purify DNA from cells, researchers use various methods of DNA extraction. While the specifics of different protocols may vary, some general concepts underlie the process of DNA extraction.
202.5K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

UnionLoops: a workflow for calling chromatin loops across related Hi-C datasets with improved specificity, precision, and sensitivity.

Genome biology·2026
Same author

Genome-wide chromatin recording resolves dynamic cell state changes.

bioRxiv : the preprint server for biology·2026
Same author

HP1β and H3K9me3 Regulate Olfactory Receptor Choice and Transcriptional Identity.

International journal of molecular sciences·2026
Same author

LncRNA-splicing factor condensates regulate hypoxia-responsive pre-mRNA processing near nuclear speckles.

Molecular cell·2026
Same author

Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons.

bioRxiv : the preprint server for biology·2026
Same author

A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability.

Nature communications·2026

Video Experimental Relacionado

Updated: Mar 22, 2026

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.2K

Una guía para empacar su ADN

Job Dekker, Mitchell Guttman, Stavros Lomvardas

    Cell
    |April 9, 2016
    PubMed
    Resumen
    Este resumen es generado por máquina.

    El material genético celular no es aleatorio. Esta conversación explora cómo ocurre la organización nuclear y su significado biológico.

    Más Videos Relacionados

    DNA Extraction from 0.22 μM Sterivex Filters and Cesium Chloride Density Gradient Centrifugation
    15:14

    DNA Extraction from 0.22 μM Sterivex Filters and Cesium Chloride Density Gradient Centrifugation

    Published on: September 18, 2009

    30.3K
    Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
    11:06

    Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

    Published on: February 24, 2014

    13.6K

    Videos de Experimentos Relacionados

    Last Updated: Mar 22, 2026

    Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
    09:32

    Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

    Published on: April 12, 2019

    7.2K
    DNA Extraction from 0.22 μM Sterivex Filters and Cesium Chloride Density Gradient Centrifugation
    15:14

    DNA Extraction from 0.22 μM Sterivex Filters and Cesium Chloride Density Gradient Centrifugation

    Published on: September 18, 2009

    30.3K
    Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
    11:06

    Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

    Published on: February 24, 2014

    13.6K

    Área de la Ciencia:

    • La genómica
    • Biología celular
    • Biología molecular

    Sus antecedentes:

    • La organización espacial del material genético dentro del núcleo celular es un determinante crítico de la función celular.
    • La comprensión de los mecanismos que rigen la arquitectura nuclear es fundamental para la biología celular.

    Objetivo del estudio:

    • Explorar los principios y las implicaciones de la organización de material genético no aleatorio dentro del núcleo celular.
    • Discutir las investigaciones en curso y las cuestiones clave en el campo de la organización nuclear.

    Principales métodos:

    • Debate de expertos y síntesis de los resultados de la investigación actual.
    • Diálogo interdisciplinario entre los principales científicos de la genómica y la biología celular.

    Principales resultados:

    • El material genético está organizado con precisión dentro del núcleo, no distribuido al azar.
    • Esta organización juega un papel crucial en la regulación de la expresión génica y otros procesos nucleares.

    Conclusiones:

    • La disposición espacial precisa del genoma es esencial para la función y la viabilidad celular.
    • Las investigaciones adicionales sobre la organización nuclear prometen importantes conocimientos sobre los procesos biológicos fundamentales.