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Hobit y Blimp1 instruyen un programa de transcripción universal de la residencia de los tejidos en los linfocitos

Laura K Mackay¹, Martina Minnich², Natasja A M Kragten³

¹Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. Australian Research Council (ARC) Centre of Excellence in Advanced Molecular Imaging, University of Melbourne, Melbourne, Australia. lkmackay@unimelb.edu.au kallies@wehi.edu.au k.vangisbergen@sanquin.nl.

Science (New York, N.Y.)

|April 23, 2016

Resumen

Los factores de transcripción Hobit y Blimp1 son cruciales para la retención del tejido en las células T de memoria (Trm) y otros linfocitos residentes en el tejido, asegurando una protección inmediata contra la reinfección.

Área de la Ciencia:

Inmunología
Biología celular
Reglamento de transcripción

Sus antecedentes:

Las células T (Trm) de memoria residentes en los tejidos ofrecen una rápida protección contra la reinfección.
La retención de células Trm implica la regulación ascendente de CD69 y la regulación descendente de la molécula de salida, pero se desconoce un regulador clave.

Objetivo del estudio:

Identificar el regulador transcripcional responsable de la retención de las células Trm en el tejido.
Investigar el papel de Hobit y Blimp1 en el desarrollo de células Trm y la residencia de tejidos.

Principales métodos:

Análisis de la expresión del factor de transcripción en las células Trm.
Estudios genéticos en ratones para evaluar la función de Hobit y Blimp1 en el desarrollo de células Trm y otros linfocitos residentes en tejidos.

Principales resultados:

Hobit está específicamente regulado en las células Trm.
El módulo Hobit-Blimp1 es esencial para el desarrollo de células Trm en la piel, el intestino, el hígado y el riñón.
Este módulo también regula otros linfocitos residentes en el tejido como las células NKT y NK.

Conclusiones:

Hobit y Blimp1 se identifican como reguladores centrales de la retención de tejidos en diversas poblaciones de linfocitos.
Un programa transcripcional común mediado por Hobit-Blimp1 gobierna la residencia del tejido.
Este hallazgo proporciona información sobre el mantenimiento de la vigilancia inmune dentro de los tejidos.

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