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Habitantes microbianos de la piel: amigos para siempre
Pieter C Dorrestein1, Richard L Gallo2, Rob Knight3
1Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; UC San Diego Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
Cell
|May 7, 2016
Resumen
Las comunidades microbianas de la piel humana están moldeadas principalmente por el individuo, no por el medio ambiente. Este estudio mapea los metagenomas de la piel a lo largo del tiempo para revelar los factores de estabilidad a largo plazo.
Área de la Ciencia:
- Microbiología
- La genómica
- El microbioma humano
Sus antecedentes:
- El microbioma de la piel humana juega un papel crucial en la salud y la enfermedad.
- Comprender la estabilidad y los impulsores de las comunidades microbianas de la piel es esencial para desarrollar intervenciones específicas.
- Estudios anteriores han explorado la composición microbiana de la piel, pero la dinámica a largo plazo sigue siendo menos comprendida.
Objetivo del estudio:
- Para investigar la estabilidad temporal del metagenoma de la piel humana.
- Identificar los factores principales que influyen en la composición de las comunidades microbianas de la piel a lo largo del tiempo.
- Proporcionar información sobre la resiliencia y la adaptabilidad del microbioma de la piel.
Principales métodos:
- Secuenciación metagenómica de muestras de piel de individuos durante un período prolongado.
- Análisis bioinformático para evaluar la composición y la diversidad de la comunidad microbiana.
- Modelado estadístico para determinar la influencia de los factores ambientales y específicos del huésped.
Principales resultados:
- La composición de la comunidad microbiana de la piel es notablemente estable dentro de los individuos con el tiempo.
- Se encontró que los factores específicos del huésped, en lugar de las influencias ambientales, eran los impulsores dominantes de la estructura de la comunidad microbiana.
- Se observó una variación interindividual significativa en los metagenomas de la piel.
Conclusiones:
- El microbioma de la piel humana exhibe un alto grado de estabilidad personal, dictado en gran medida por el huésped.
- Estos hallazgos tienen implicaciones para la comprensión de la salud de la piel, la patogénesis de la enfermedad y el desarrollo de terapias basadas en el microbioma.
- La investigación futura debe centrarse en aclarar los factores específicos del huésped que rigen el ensamblaje de la comunidad microbiana de la piel.
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