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SIRT6 suprime el cáncer de páncreas mediante el control de Lin28b

Sita Kugel1, Carlos Sebastián1, Julien Fitamant1

  • 1The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA; The MGH Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA.

Cell
|May 17, 2016
PubMed
Resumen

La sirtuina 6 (SIRT6) suprime el cáncer de páncreas mediante la regulación de Lin28b, una vía de microARN. La pérdida de SIRT6 promueve la progresión y la metástasis de PDAC, identificando un objetivo terapéutico en un subconjunto de pacientes.

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